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Propranolol, an antagonist of \u03b2\u2010adrenergic receptors, has shown potential in alleviating TMD\u2010associated pain, particularly when the level of catecholamines is elevated. The aim of this study was to explore whether intra\u2010articular propranolol administration is effective in diminishing temporomandibular joint (TMJ) pain during repeated stress situations. Additionally, we investigated the effect of repeated stress on the expression of genes encoding \u03b2\u2010adrenoceptors in the trigeminal ganglion. In the present study, rats were exposed to a stress protocol induced by sound, then to the administration of formalin in the TMJ (to elicit a nociceptive response), followed immediately afterward by different doses of propranolol, after which the analgesic response to propranolol was evaluated. We also assessed the levels of beta\u20101 and beta\u20102 adrenergic receptor mRNAs (<jats:italic>Adrb1<\/jats:italic> and <jats:italic>Adrb2<\/jats:italic>, respectively) using reverse transcription\u2013quantitative PCR (RT\u2010qPCR). Our findings revealed that propranolol administration reduces formalin\u2010induced TMJ nociception more effectively in stressed rats than in non\u2010stressed rats. Furthermore, repeated stress decreases the expression of the <jats:italic>Adrb2<\/jats:italic> gene within the trigeminal ganglion. The findings of this study are noteworthy as they suggest that individuals with a chronic stress history might find potential benefits from \u03b2\u2010blockers in TMD treatment.<\/jats:p>","DOI":"10.1111\/eos.12957","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T06:19:05Z","timestamp":1698819545000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of propranolol on temporomandibular joint pain in repeatedly stressed rats"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5606-4503","authenticated-orcid":false,"given":"Fernanda Barchesi","family":"Zanelatto","sequence":"first","affiliation":[{"name":"Department of Structural and Functional Biology Institute of Biology University of Campinas \u2013 UNICAMP  Campinas S\u00e3o Paulo 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