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This systematic review and meta\u2010analysis, conducted in accordance with the PRISMA guidelines, aimed to determine whether the modified Schirmer test can be used to identify dry mouth. The databases of PubMed, Scopus, ScienceDirect, and CENTRAL (CRD42023393843) were systematically searched to retrieve articles published until 9th November 2023. Among the 343 original articles retrieved, six met the inclusion criteria. A total of 1150 patients, comprising 710 (61.7%) women and 440 (38.3%) men (mean age, 47.1\u00a0\u00b1\u00a07.3 years), were included. The meta\u2010analysis revealed a weak correlation coefficient of \u00a0= 0.42 (95% Cl: 0.29\u20130.55) between MST and the unstimulated salivary flow rate. Therefore, while the MST might offer a simple and accessible alternative for initial screening in the future, especially in non\u2010specialized settings, its variability in sensitivity and specificity, along with an actual lack of standardization, necessitates cautious interpretation. Further studies are necessary before recommending the test in clinical routine.<\/jats:p>","DOI":"10.1111\/eos.12977","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T07:52:50Z","timestamp":1708329170000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Use of the modified Schirmer test to measure salivary gland hypofunction\/hyposalivation: Systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3269-8920","authenticated-orcid":false,"given":"Christoph Matthias","family":"Schoppmeier","sequence":"first","affiliation":[{"name":"Faculty of Medicine and University Hospital Cologne Polyclinic for Operative Dentistry and Periodontology University of Cologne  Cologne 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