{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:20:54Z","timestamp":1785892854294,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim was to evaluate the effect of probiotics\u2010containing beverages on dental caries development by a systematic review and meta\u2010analysis (PROSPERO CRD42021258010). PubMed, Embase, and Web of Science databases were assessed (up to October 2023) for randomized placebo\u2010controlled trials that evaluated the consumption of probiotics\u2010containing beverages having dental caries as endpoint. Risk of bias assessment (Cochrane Handbook) was performed for all studies. Risk ratio (RR), standardized mean difference (SMD) and 95% confidence interval (CI), were calculated for caries prevalence and caries increment, respectively. Meta\u2010analysis was performed. Qualitative analysis of more than 2000 individuals aged from 1 to 84 years (9 studies) showed inconsistent effects of these probiotics\u2010containing beverages. Synthesis of more than 1000 children and adolescents did not demonstrate a statistically significant difference in the proportion of individuals with cavitated lesions (RR 0.60 [95 % CI 0.34 to 1.08]; <jats:italic>n<\/jats:italic>\u00a0=\u00a02), but a significantly smaller increment of both cavitated and non\u2010cavitated carious lesions (SMD \u22120.23 [95 % CI \u22120.39 to \u22120.08]; <jats:italic>n<\/jats:italic>\u00a0=\u00a04) was related to the consumption of probiotics\u2010containing beverages. Certainty of evidence for caries prevalence and caries increment were moderate and low, respectively. Current evidence is not substantial to strengthen the impact of these beverages on caries development.<\/jats:p>","DOI":"10.1111\/eos.12980","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T14:24:39Z","timestamp":1709821479000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Probiotics\u2010containing beverages and dental caries: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1481-8546","authenticated-orcid":false,"given":"Alexandra","family":"Feldmann","sequence":"first","affiliation":[{"name":"Preventive and Community Dentistry Department Dental School Federal University of Rio Grande do Sul (UFRGS)  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9813-5995","authenticated-orcid":false,"given":"Gustavo","family":"Eidt","sequence":"additional","affiliation":[{"name":"Preventive and Community Dentistry Department Dental School Federal University of Rio Grande do Sul (UFRGS)  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4567-1978","authenticated-orcid":false,"given":"Sandra Liana","family":"Henz","sequence":"additional","affiliation":[{"name":"Preventive and Community Dentistry Department Dental School Federal University of Rio Grande do Sul (UFRGS)  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8107-413X","authenticated-orcid":false,"given":"Rodrigo Alex","family":"Arthur","sequence":"additional","affiliation":[{"name":"Preventive and Community Dentistry Department Dental School Federal University of Rio Grande do Sul (UFRGS)  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-food-032519-051708"},{"key":"e_1_2_9_3_1","first-page":"S26","article-title":"Danone\u202f: the gut microbiome and probiotics \u2013100 years of shared history","volume":"577","author":"Veiga P","year":"2020","journal-title":"Danon Nutr Res"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2017.1345414"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517735295"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000499037"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11070880"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/jpbs.jpbs_801_21"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/app11125472"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41415-021-3775-4"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-014-1228-z"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2016.03.002"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-018-2682-9"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3920\/BM2021.0008"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2022.2077693"},{"key":"e_1_2_9_16_1","first-page":"85","article-title":"Effects of probiotics on preventing caries in preschool children: a systematic review and meta\u2010analysis","volume":"47","author":"Meng N","year":"2023","journal-title":"J Clin Pediatr Dent"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2022.111228"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1120995"},{"key":"e_1_2_9_19_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions version 6.4","author":"Higgins JPT","year":"2023"},{"key":"e_1_2_9_20_1","unstructured":"GRADEpro GDT: GRADEpro Guideline Development Tool [Software].McMaster University and Evidence Prime.2023. Available from gradepro.org. Accessed 23 Sept 2023 as available at:https:\/\/www.gradepro.org\/terms\/cite"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000047484"},{"key":"e_1_2_9_22_1","first-page":"221","article-title":"Effect of consumption of Lactobacillus rhamnosus GG and calcium, in carrot\u2010pineapple juice on dental caries risk in children","volume":"5","author":"Pohjavuori S","year":"2010","journal-title":"Int J Probiotics Prebiotics"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2011.568962"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016357.2018.1453083"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfpp.14147"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000509926"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj3020043"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515623935"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678\u20107757\u20102017\u20100318"},{"key":"e_1_2_9_30_1","volume-title":"Oral Health Surveys: Basic Methods","author":"World Health Organization","year":"2013"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2007.00347.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-020-03712-8"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010015\u20100096\u20105"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000235581"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350524"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000348424"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-020-09652-9"}],"container-title":["European Journal of Oral Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eos.12980","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T13:31:07Z","timestamp":1715779867000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eos.12980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,7]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/eos.12980"],"URL":"https:\/\/doi.org\/10.1111\/eos.12980","archive":["Portico"],"relation":{},"ISSN":["0909-8836","1600-0722"],"issn-type":[{"value":"0909-8836","type":"print"},{"value":"1600-0722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,7]]},"assertion":[{"value":"2023-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12980"}}