{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T23:23:55Z","timestamp":1772148235314,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present study aimed to evaluate whether epigenetic markers are expressed in the dental follicles surrounding ectopically erupting teeth. Twenty\u2010one dental follicles were collected in 20 adolescent children through surgical exposure of ectopic teeth. The epigenetic modifications of DNA methylation and histone acetylation were evaluated by immunohistochemistry. The results showed cells positive for DNA\u2010methyltransferase 1 (DNMT1), DNA methyltransferase 3 beta (DNMT3B), ten\u2010eleven translocation\u20102 (TET2), acetyl\u2010histone H3 (AcH3), acetyl\u2010histone H4 (AcH4), 5\u2010methylcytosine (5mC), and 5\u2010hydroxymethylcytosine (5hmC) were present in all the samples. The levels of epigenetic markers representing active chromatin (5hmC, AcH3, AcH4, and TET2) were statistically significantly higher than those of markers representing inactive chromatin (5mC, DNMT3B, DNMT1). In conclusion, follicles in ectopic teeth display major epigenetic modifications. In the follicles, epigenetic markers associated with the activation of bone\u2010related genes are more abundant than markers associated with the inactivation of bone\u2010related genes.<\/jats:p>","DOI":"10.1111\/eos.13005","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T03:15:56Z","timestamp":1721186156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Epigenetic markers of tooth eruption \u2013 DNA methylation and histone acetylation"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2438-8516","authenticated-orcid":false,"given":"Anna","family":"Westerlund","sequence":"first","affiliation":[{"name":"Department of Orthodontics, Institute of Odontology, The Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1522-1903","authenticated-orcid":false,"given":"Asal","family":"Shikhan","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Institute of Odontology, The Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6707-4811","authenticated-orcid":false,"given":"Nina","family":"Sabel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Institute of Odontology, The Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5186-2645","authenticated-orcid":false,"given":"Farah","family":"Asa'ad","sequence":"additional","affiliation":[{"name":"Department of Oral Biochemistry, Institute of Odontology, The Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7908-5956","authenticated-orcid":false,"given":"Lena","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Oral Biochemistry, Institute of Odontology, The Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"12","article-title":"The prevalence of malocclusion in Swedish schoolchildren","volume":"81","author":"Thilander B","year":"1973","journal-title":"Scand J Dent Res"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12000"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12568"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-018-0342-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2006.00406.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345890680021001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001680303"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-6343.2007.00404.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.140559"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12453"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12657"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2012.05.016"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1170116"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1169786"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-015-0109-x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05767.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12155"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574888X12666170530100524"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-018-9785-0"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24668"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2012.0711"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2019.0124"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2010.0180"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.07.160"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8882857"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2020.104856"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-004-4201-1"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0685-2"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29695"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-016-2485-9"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3774"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2013-0770"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbir.1998.0240"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.06.006"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1016-8478(23)17408-5"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.7.1.18753"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00210"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12281"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-018-2826-x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-64402007000200011"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2011.01058.x"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2014.02.013"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2010.12.003"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112440200"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi982171a"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-08-2622"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.9.5809"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M507213200"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.07.034"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22684"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-8-362"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050813"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20544"}],"container-title":["European Journal of Oral Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eos.13005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T09:06:43Z","timestamp":1721984803000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eos.13005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,16]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/eos.13005"],"URL":"https:\/\/doi.org\/10.1111\/eos.13005","archive":["Portico"],"relation":{},"ISSN":["0909-8836","1600-0722"],"issn-type":[{"value":"0909-8836","type":"print"},{"value":"1600-0722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,16]]},"assertion":[{"value":"2024-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13005"}}