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Solutions F, FSn, AA, F+AA, FSn+AA, and deionized water as negative control were tested. Bovine enamel and dentin specimens (<jats:italic>n<\/jats:italic>\u00a0=\u00a013\/solution\/substrate) underwent a set of erosion\u2010abrasion cycles (0.3% citric acid [5\u00a0min, 4\u00d7\/day], human saliva [1\u00a0h, 4\u00d7\/day], brushing [15 s, 2\u00d7\/day], and treatments [2\u00a0min, 2\u00d7\/day]) for each of five days. Initial enamel erosion was evaluated using Knoop microhardness after the first and second acid challenge on day 1, and surface loss with profilometry after day 5. KOH\u2010soluble fluoride was assessed. Data were analyzed with ANOVA\/Tukey tests. The combination of fluoride and AA resulted in higher protection against enamel erosion, whereas this was not the case for the combination of AA and FSn. All treatments protected against enamel and dentin loss. The lowest surface loss values were observed with F+AA and FSn+AA. The polymer did not significantly influence the KOH\u2010soluble fluoride formation on enamel\/dentin specimens. The aminomethacrylate copolymer effectively enhanced the efficacy of sodium fluoride against initial erosion and improved the control of enamel and dentin wear of F and FSn solutions.<\/jats:p>","DOI":"10.1111\/eos.13015","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T04:23:55Z","timestamp":1724991835000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of combining aminomethacrylate and fluoride against erosive and abrasive challenges on enamel and dentin"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3293-082X","authenticated-orcid":false,"given":"Marina Gullo","family":"Augusto","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry Institute of Science and Technology S\u00e3o Paulo State University \u2013 UNESP  S\u00e3o Jos\u00e9 dos Campos S\u00e3o Paulo Brazil"},{"name":"School of Dentistry Centro 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