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Triggering receptors expressed on myeloid cells (TREMs) are a group of receptor molecules extensively present on myeloid cell surfaces, crucial in the regulation of inflammatory process. Our analysis of transcriptomic sequencing data from clinical pulp samples of dataset GSE77459 and animal models revealed up\u2010regulation of Trem1 during pulpitis. Administration of the Trem1\u2010blocking peptide LP17 led to lower (more than 1\u2010fold) levels of several pro\u2010inflammatory factors and inhibition of M1 macrophage polarization both in vivo and in vitro. This study of the expression patterns and functions of Trem1 in the development of dental pulp inflammation provides novel insights into the therapeutic strategies for clinical pulpitis.<\/jats:p>","DOI":"10.1111\/eos.13018","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T05:20:00Z","timestamp":1726204800000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of blockage of Trem1 on the M1 polarization of macrophages in the regulation dental pulp inflammation"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4532-7456","authenticated-orcid":false,"given":"Ting\u2010Ting","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Bengbu Medical University  Bengbu Anhui 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