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IL\u201017\/IL\u201017A (IL\u201017A) is a pro\u2010inflammatory cytokine secreted by T helper (Th) 17 cells following their recruitment to inflamed sites; however, the roles of IL\u201017A during pulpitis remain unclear. The purpose of this study was to investigate the effect of IL\u201017A on IL\u20106, IL\u20108, CCL20 and CXCL10 production by human dental pulp fibroblasts (HDPFs) in vitro. IL\u201017A at a concentration of 100\u00a0ng\/ml induced the production of 10 times more IL\u20108 and 4 times more CXCL10, but not IL\u20106 and CCL20, compared to controls. Co\u2010stimulation of HDPFs with IL\u201017A and IL\u20101\u03b2 synergistically enhanced the production of IL\u20106, CCL20, IL\u20108 and CXCL10. IL\u20101\u03b2 increased expression of IL\u201017 receptor\/IL\u201017RA (IL\u201017R) on HDPFs. Moreover, the cell signal pathways of p38 mitogen\u2010activated protein kinase (MAPK) and nuclear factor\u2010\u03baB (NF\u2010\u03baB) were more potently activated by simultaneous stimulation with IL\u201017A and IL\u20101\u03b2. These findings suggest that IL\u201017A participates in the progression of dental pulp inflammation through the enhanced production of inflammatory mediators in HDPFs.<\/jats:p>","DOI":"10.1111\/eos.13019","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T16:09:19Z","timestamp":1726848559000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of interleukin\u201017A on inflammatory mediator production in interleukin\u20101\u03b2\u2010stimulated human dental pulp fibroblasts"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2727-7531","authenticated-orcid":false,"given":"Tadashi","family":"Nakanishi","sequence":"first","affiliation":[{"name":"Department of Regenerative Dental Medicine Tokushima University Graduate School of Biomedical Sciences  Tokushima 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