{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:49:19Z","timestamp":1791348559955,"version":"4.3.1"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The current study aimed to assess the effect of thyme honey on pain relief in patients with minor aphthous ulcers as a primary objective, its healing effect on ulcer size reduction, and the Oral Health Impact Profile (OHIP\u201014). In this randomized clinical trial, 30 patients (15 in each group) having minor aphthous ulcers at the oral diagnostic clinic at the British University in Egypt were treated with either thyme honey or triamcinolone acetonide in orabase. Different clinical parameters\u00a0were recorded for both groups at various intervals, such as pain intensity using the Visual Analog Scale (VAS), size of ulcers in mm, and OHIP\u201014. Thyme honey intervention showed more significant ulcer size reduction than the\u00a0triamcinolone acetonide group on days 5, and 7, and a more substantial decrease in pain intensity on days 3, 5, and 7. Additionally, the thyme honey group showed significantly lower OHIP values than the triamcinolone acetonide group after 7 days. The current clinical trial furnished evidence of the effectiveness of thyme honey in managing minor aphthous ulcers for the first time and revealed clinical efficiency with satisfactory patient outcomes.<\/jats:p>","DOI":"10.1111\/eos.13032","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T08:56:42Z","timestamp":1735203402000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy of thyme honey in the management of oral aphthous ulcers: A randomized controlled clinical trial"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2541-7243","authenticated-orcid":false,"given":"Dalia","family":"Ghalwash","sequence":"first","affiliation":[{"name":"Oral Medicine and Periodontology Faculty of Dentistry The British University in Egypt El Sherouk City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7958-7216","authenticated-orcid":false,"given":"Ayman","family":"El\u2010Gawish","sequence":"additional","affiliation":[{"name":"Oral Medicine and Periodontology Faculty of Dentistry The British University in Egypt El Sherouk City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0249-7295","authenticated-orcid":false,"given":"Ahmed","family":"Ammar","sequence":"additional","affiliation":[{"name":"Oral Medicine and Periodontology Faculty of Dentistry The British University in Egypt El Sherouk City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5069-8257","authenticated-orcid":false,"given":"Asmaa","family":"Abou\u2010Bakr","sequence":"additional","affiliation":[{"name":"Oral Medicine and Periodontology Faculty of Dentistry Galala University Suez Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.1104a99"},{"key":"e_1_2_8_3_1","first-page":"26","article-title":"Recurrent aphthous stomatitis: a review","volume":"10","author":"Edgar NR","year":"2017","journal-title":"J Clin Aesthetic Dermatol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/njms.NJMS_249_20"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.19082\/6912"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201059349\u2010w"},{"key":"e_1_2_8_7_1","first-page":"27","article-title":"The effect of honey as a treatment for oral ulcerative lesions: a systematic review","volume":"5","author":"Hunter M","year":"2020","journal-title":"Explor Res Hypothesis Med"},{"key":"e_1_2_8_8_1","first-page":"3","article-title":"Muco\u2010bioadhesive containing ginger officinale extract in the management of recurrent aphthous stomatitis: a randomized clinical study","volume":"6","author":"Haghpanah P","year":"2015","journal-title":"Caspian J Intern Med"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-018-2733-x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01706.x"},{"key":"e_1_2_8_11_1","first-page":"1","article-title":"Herbal therapy in periodontics: a review","volume":"3","author":"Anand B","year":"2017","journal-title":"J Res Pharm Sci"},{"key":"e_1_2_8_12_1","first-page":"141","article-title":"Honey: a biologic wound dressing","volume":"27","author":"Molan PC","year":"2015","journal-title":"Wounds"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2016.05.008"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00217-014-2297-6"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20030764"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5843615"},{"key":"e_1_2_8_17_1","first-page":"691","article-title":"Efficacy of honey in comparison to topical corticosteroid for treatment of recurrent minor aphthous ulceration: aA randomized, blind, controlled, parallel, double\u2010center clinical trial","volume":"45","author":"El\u2010Haddad SA","year":"2014","journal-title":"Quintessence Int"},{"key":"e_1_2_8_18_1","first-page":"449","article-title":"To evaluate the efficiency of curcumin and honey in patients with recurrent aphthous stomatitis: a randomized clinical controlled trial","volume":"6","author":"Pandharipande R","year":"2019","journal-title":"Int J Res Rev"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.21608\/asmj.2022.285465"},{"key":"e_1_2_8_20_1","first-page":"12","article-title":"Effectiveness of honey, and aloe vera in the treatment of minor aphthous ulcer among young adults\u2010A single blinded randomized clinical trial","volume":"9","author":"Mir H","year":"2022","journal-title":"Int J Sci Study"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.22541\/au.167784423.37540560\/v1"},{"key":"e_1_2_8_22_1","first-page":"263","article-title":"Antioxidant effects of Thyme (Thymus vulgaris) extract on ram sperm quality during cryopreservation","volume":"8","author":"Vahedi V","year":"2018","journal-title":"Iran J Appl Anim Sci"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001\u2010023\u201001351\u20109"},{"key":"e_1_2_8_24_1","first-page":"23","article-title":"Antimicrobial activity of thyme honey from Morocco against pathogenic bacteria","volume":"32","author":"Bendahbia K","year":"2020","journal-title":"J Hyg Eng Des"},{"key":"e_1_2_8_25_1","first-page":"545","article-title":"Evaluation of the effects of local application of thyme honey in open cutaneous wound healing","volume":"46","author":"Takzaree N","year":"2017","journal-title":"Iran J Public Health"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.14202\/vetworld.2021.292-301"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11010028"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010023\u201007943\u20109"},{"key":"e_1_2_8_29_1","first-page":"1","article-title":"Comparison of efficacy of natural honey and triamcinolone acetonide (0.1%) in the healing of oral ulcers\u2014a clinical study","volume":"3","author":"Gupta SV","year":"2017","journal-title":"J Apither"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13353"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010018\u20100620\u20105"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1997.tb00941.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imr.2014.03.001"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8839898"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-020-04459-6"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2017.11.022"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fpsl.2020.100578"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2017.01.001"},{"key":"e_1_2_8_40_1","first-page":"770","article-title":"A comparison study on the effectiveness of local honey and salicylate gel for the treatment of minor recurrent aphthous stomatitis","volume":"20","author":"Halim DS","year":"2013","journal-title":"Int Med J"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517709737"},{"key":"e_1_2_8_42_1","first-page":"302","article-title":"The diagnostic and prognostic value of salivary sCD44 level determination in oral malignant and potentially premalignant lesions","volume":"6","author":"Ghalwash DM","year":"2012","journal-title":"Adv Environ Biol"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoms.2020.06.013"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2018.04.003"},{"key":"e_1_2_8_45_1","first-page":"73","article-title":"Effect of topical application of pure honey in chemo\u2010radiation\u2010induced mucositis and its clinical benefits in improving quality of life in patients of oral squamous cell carcinoma","volume":"18","author":"Howlader D","year":"2019","journal-title":"J Maxillofac Surg"}],"container-title":["European Journal of Oral Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eos.13032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T23:25:00Z","timestamp":1745537100000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eos.13032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,26]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/eos.13032"],"URL":"https:\/\/doi.org\/10.1111\/eos.13032","archive":["Portico"],"relation":{},"ISSN":["0909-8836","1600-0722"],"issn-type":[{"value":"0909-8836","type":"print"},{"value":"1600-0722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,26]]},"assertion":[{"value":"2024-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13032"}}