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However, there are few studies on the effect of glucocorticoids on alveolar bone. The\u00a0aim\u00a0of the present study was to evaluate the impact of chronic administration of glucocorticoids on osteocytes and the lacuno\u2010canalicular system of maxillary and mandibular alveolar bone in growing rats. Male Wistar rats were administered intramuscular dexamethasone (7\u00a0mg\/kg b.w.) or saline solution once a week for 5 weeks. After euthanasia, mandibles and upper maxillae were resected and processed for micro\u2010computed tomography, histological, and immunohistochemical evaluation. Glucocorticoids induced morphological changes in the lacuno\u2010canalicular system and apoptosis of alveolar bone osteocytes and had no effect on SOST\/sclerostin osteocyte expression. Our findings suggest that the deleterious effect of glucocorticoids on alveolar bone is associated with osteocyte apoptosis and lacuno\u2010canalicular system changes, whereas Wnt\/\u03b2 catenin pathway regulation in osteocytes appears to play no significant role in the pathogenesis of glucocorticoid\u2010induced bone loss.<\/jats:p>","DOI":"10.1111\/eos.70000","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T09:51:34Z","timestamp":1739267494000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of glucocorticoids on osteocytes and on the lacuno\u2010canalicular system of maxillary and mandibular alveolar bone"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2922-5807","authenticated-orcid":false,"given":"Juliana","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology School of Dentistry 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