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Eight databases (PubMed, SciELO, Scopus, EMBASE, Web of Science, Science Direct, LILACS, and Livivo) and three \u201cgray literature\u201d sources (Open Access Theses and Dissertations [OATD], Open Grey, and ProQuest) were used. Preferred Reporting Items for Systematic reviews and Meta\u2010Analyses (PRISMA) guidelines were followed, and methodology quality was assessed using the QUIN tool. The review included in vitro studies investigating the effect of 38% SDF on demineralized permanent dentin. The primary outcomes were findings from energy\u2010dispersive X\u2010ray spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), and X\u2010ray diffraction (XRD) approaches, while secondary outcomes included findings from hardness testing, micro\u2010computed tomography (micro\u2010CT), and scanning electron microscopy. From 16,630 results, 17 studies met the eligibility criteria. After treatment with 38% SDF, significant increases were observed in the levels of calcium (Ca) and phosphorus (P) in dentin. Higher mineral\/matrix ratios and a significantly lower amide I\/HPO<jats:sup>2\u2212<\/jats:sup> ratio were identified, using FITR, in groups treated with SDF. Restoration of dentin crystallinity in groups treated with SDF, with sharp peaks for silver chloride and silver, were shown using XRD. Micro\u2010computed tomography revealed reduced lesion depth, while scanning electron microscopy showed smoother surfaces and partial occlusion of tubules. Risk of bias was moderate in 13 studies and high in four. Overall, 38% SDF reduces demineralization, preserves mineral content, increases the levels of Ca and P, and enhances mineral\/matrix ratios, demonstrating potential for managing demineralization.<\/jats:p>","DOI":"10.1111\/eos.70023","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T21:28:52Z","timestamp":1749677332000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of silver diamine fluoride in human dentin: A systematic review of in vitro studies"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8148-5809","authenticated-orcid":false,"given":"Andressa Cardoso","family":"Amorim","sequence":"first","affiliation":[{"name":"Department of Operative Dentistry and Dental Materials Dental School, Federal University of Uberlandia  Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9231-0895","authenticated-orcid":false,"given":"Allyne Jorcelino Daloia de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Dental Materials Dental School, Federal University of Uberlandia  Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4784-5118","authenticated-orcid":false,"given":"Mary Stefany Andrade","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Dental Materials Dental School, Federal University of Uberlandia  Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7116-1547","authenticated-orcid":false,"given":"Meire Coelho","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry CEUMA University  S\u00e3o Lu\u00eds Maranh\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9017-2946","authenticated-orcid":false,"given":"Veridiana Resende","family":"Novais","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Dental Materials Dental School, Federal University of Uberlandia  Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1997.tb00894.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.30"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000503309"},{"key":"e_1_2_8_5_1","unstructured":"Global Burden of Disease Collaborative Network.Seattle: Global Burden of Disease Study 2019 (GBD 2019).Institute for Health Metrics and Evaluation;2021. 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