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Forty\u2010eight sound human teeth were randomly divided into eight experimental groups, based on three factors: the type of SARC, the presence or absence of an MDP agent, and the presence or absence of multiple saliva exposures. The control group for each SARC received neither MDP agent nor multiple saliva contaminations. For each group, five teeth were sectioned to obtain 30\u201344 beams, followed by \u00b5TBS testing, fracture mode analysis, and scanning electron microscopy. Data were analyzed using one\u2010way and two\u2010way analysis of variance, Scheff\u00e9\u2019s test, and Weibull statistics. Under uncontaminated conditions, the application of MDP agents was found to significantly enhance the bond strength of both SARCs. Saliva contamination significantly reduced \u00b5TBS, regardless of the cement used. However, when MDP agents were applied prior to bonding, \u00b5TBS values remained comparable to those of uncontaminated controls, even after multiple saliva exposures. These results support the use of MDP agents to maintain adhesive integrity in the presence of repeated salivary contaminations, offering greater reliability in adverse clinical environments.<\/jats:p>","DOI":"10.1111\/eos.70036","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T07:17:50Z","timestamp":1755501470000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of MDP agents on the bond strength of two self\u2010adhesive resin cements to saliva\u2010contaminated dentin substrates"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8535-8623","authenticated-orcid":false,"given":"Anna","family":"Francescato","sequence":"first","affiliation":[{"name":"Department of Industrial Engineering University of Padova Padova Italy"},{"name":"UMR Sant\u00e9 Orale \u2013 UMR 1333  Montrouge France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8135-1587","authenticated-orcid":false,"given":"Am\u00e9lie","family":"Mainjot","sequence":"additional","affiliation":[{"name":"Department of Fixed Prosthodontics, Institute of Dentistry University of Li\u00e8ge  Li\u00e8ge Belgium"},{"name":"Dental Biomaterials Research Unit (d\u2010BRU), Institute of Dentistry University of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2988-2145","authenticated-orcid":false,"given":"Julia","family":"Bosco","sequence":"additional","affiliation":[{"name":"UMR Sant\u00e9 Orale \u2013 UMR 1333  Montrouge France"},{"name":"UFR d'Odontologie Universit\u00e9 Paris Cit\u00e9 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1255-672X","authenticated-orcid":false,"given":"St\u00e9phane Le","family":"Goff","sequence":"additional","affiliation":[{"name":"UMR Sant\u00e9 Orale \u2013 UMR 1333  Montrouge France"},{"name":"UFR d'Odontologie Universit\u00e9 Paris Cit\u00e9 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7917-0111","authenticated-orcid":false,"given":"Jean\u2010Fran\u00e7ois","family":"Nguyen","sequence":"additional","affiliation":[{"name":"UMR Sant\u00e9 Orale \u2013 UMR 1333  Montrouge France"},{"name":"UFR d'Odontologie Universit\u00e9 Paris Cit\u00e9 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8000-3054","authenticated-orcid":false,"given":"Marjorie","family":"Zanini","sequence":"additional","affiliation":[{"name":"UMR Sant\u00e9 Orale \u2013 UMR 1333  Montrouge France"},{"name":"UFR d'Odontologie Universit\u00e9 Paris Cit\u00e9 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2017.06.006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jerd.13036"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-013-1173-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2010.02148.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808701012"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2009.00623.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2010.01831.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2341\/19-153-L"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2024.04.027"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2009.07.007"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpr.2001.113778"},{"key":"e_1_2_8_13_1","first-page":"106","article-title":"An essential component to adhesive dentistry: the rubber dam","volume":"17","author":"Douglas AT","year":"2005","journal-title":"Pr Proced Aesthet Dent"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1989.0131"},{"key":"e_1_2_8_15_1","first-page":"156","article-title":"Adverse effects of salivary contamination for adhesives in restorative dentistry. 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