{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T02:23:15Z","timestamp":1783045395141,"version":"3.54.6"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401086"],"award-info":[{"award-number":["82401086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Periodontitis arises from dysbiosis of the oral microbiome and excessive host immune responses, with the C5a\u2013C5aR axis playing a key role in destructive inflammation. This study evaluated the efficacy of the C5aR antagonist W54011 in treating experimental periodontitis in mice. A ligature\u2010induced periodontitis model combined with localized\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    lipopolysaccharide (LPS) injection was established to mimic human disease progression. Periodontal inflammation was assessed by measuring TNF\u2010\u03b1 and IL\u20106 levels via enzyme\u2010linked immunosorbent assay and real\u2010time quantitative polymerase chain reaction, while C5aR expression was analyzed by western blot and immunohistochemistry. Micro\u2010computed tomography (micro\u2010CT) quantified alveolar bone resorption. Results showed that TNF\u2010\u03b1, IL\u20106, and C5aR expression was significantly upregulated in periodontitis\u2010affected mice compared to healthy controls. W54011 treatment effectively suppressed these inflammatory mediators and reduced C5aR expression. Furthermore, micro\u2010CT revealed that W54011 significantly attenuated bone loss, preserving periodontal architecture. These findings demonstrate that pharmacological blockade of C5aR with W54011 attenuates periodontal inflammation and reduces alveolar bone destruction, suggesting its potential as a novel host\u2010modulation therapy for periodontitis. The study provides mechanistic insights into C5a\u2013C5aR signaling in periodontitis pathogenesis while proposing a promising therapeutic strategy.\n                  <\/jats:p>","DOI":"10.1111\/eos.70054","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T05:32:13Z","timestamp":1764221533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Complement C5a receptor antagonist in the treatment of experimental periodontitis in mice"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6285-4648","authenticated-orcid":false,"given":"Yan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Stomatology The Fourth Affiliated Hospital of Heilongjiang University of Chinese Medicine  Harbin Heilongjiang China"},{"name":"State Key Laboratory of Frigid Zone Cardiovascular Diseases  Harbin Heilongjiang 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