{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:50:32Z","timestamp":1789149032409,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The\n                    <jats:italic>APOE4<\/jats:italic>\n                    gene, particularly the \u03b54 allele, is linked to susceptibility to Alzheimer's disease, and periodontitis can cause pathological changes in multiple organs, but combined effects of these conditions and the impact of tumor necrosis factor (TNF)\u2010\u03b1 regulation on the combined effects remain unclear. We examined the alterations in oral and non\u2010oral tissues in\n                    <jats:italic>APOE4<\/jats:italic>\n                    \u2010knockin mice with periodontitis and evaluated the effects of infliximab, a TNF\u2010\u03b1 inhibitor. Mice were grouped as control, periodontitis,\n                    <jats:italic>APOE4<\/jats:italic>\n                    \u2010knockin,\n                    <jats:italic>APOE4<\/jats:italic>\n                    \u2010knockin with periodontitis, infliximab\u2010treated periodontitis, and infliximab\u2010treated\n                    <jats:italic>APOE4<\/jats:italic>\n                    \u2010knockin with periodontitis. There were no differences in alveolar bone volume and periodontal inflammatory cells among all periodontitis\u2010induced groups. The\n                    <jats:italic>APOE4<\/jats:italic>\n                    \u2010knockin with periodontitis group showed a decrease in hippocampal Cornu Ammonis 1 neurons (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05) and increased renal and hepatic fibrosis (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05) compared to control group. The infliximab\u2010treated\n                    <jats:italic>APOE4<\/jats:italic>\n                    \u2010knockin with periodontitis group had even greater neuronal loss (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001) and renal fibrosis (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.01). Glial fibrillary acidic protein mRNA expression, a marker of astrocyte activation, was higher in the infliximab\u2010treated\n                    <jats:italic>APOE4<\/jats:italic>\n                    \u2010knockin with periodontitis group than in the control group. These suggest that\n                    <jats:italic>APOE4<\/jats:italic>\n                    with periodontitis worsens neuronal loss and renal and hepatic fibrosis, and TNF\u2010\u03b1 inhibition in this coexistence may have harmful effects on both the brain and kidney.\n                  <\/jats:p>","DOI":"10.1111\/eos.70091","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T06:53:01Z","timestamp":1775631181000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Alteration in oral and non\u2010oral tissues in ligature\u2010induced periodontitis mice with the Alzheimer's disease risk factor\n                    <i>APOE4<\/i>"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5661-9596","authenticated-orcid":false,"given":"Ae Ri","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Oral Biology Yonsei University College of Dentistry  Seoul Republic of Korea"},{"name":"BK21 FOUR Project Yonsei University College of Dentistry  Seoul Republic of Korea"},{"name":"Department of Biomedical Science Hwasung Medi\u2010Science University  Hwaseong Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0045-9597","authenticated-orcid":false,"given":"Yun\u2010Jung","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Oral Biology Yonsei University College of Dentistry  Seoul Republic of Korea"},{"name":"Department of Dentistry The Graduate School Yonsei University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7976-8594","authenticated-orcid":false,"given":"Eun\u2010Jung","family":"Bak","sequence":"additional","affiliation":[{"name":"Department of Oral Biology Yonsei University College of Dentistry  Seoul Republic of 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