{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:03:45Z","timestamp":1789650225222,"version":"4.0.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dental resin monomers are widely used in restorative dentistry, yet their potential effects on kidney\u2010related cell types remain poorly understood. This study investigated the effects of bisphenol A\u2010glycidyl methacrylate (Bis\u2010GMA) and triethylene glycol dimethacrylate (TEGDMA) on protein expression and cytoskeletal regulatory pathways in human mesangial cells. A proteomic analysis demonstrated differential expression of multiple members of the annexin A protein family in treated human mesangial cells compared with vehicle\u2010treated controls. These findings were validated by western blotting and densitometric analysis, which revealed reduced expression of annexin A proteins, including annexin A2 and annexin A5, following exposure to TEGDMA. To further explore the functional relevance of annexin A2, transient knockdown using small interfering RNA was performed. Reduction of annexin A2 expression using siRNA resulted in decreased levels of alpha\u2010smooth muscle actin and non\u2010muscle myosin proteins compared with cells transfected with non\u2010targeting control RNA. Collectively, these results indicate that commonly used dental resin monomers may influence protein expression and cytoskeletal\u2010associated pathways in human mesangial cells through alterations in annexin A protein expression. The findings highlight a previously underexplored cellular response to dental methacrylates and suggest potential implications for renal cell biology under controlled in vitro conditions.<\/jats:p>","DOI":"10.1111\/eos.70095","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:39:19Z","timestamp":1778567959000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of triethylene glycol dimethacrylate and bisphenol A\u2010glycidyl methacrylate on annexin A proteins in human mesangial cells"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5355-7967","authenticated-orcid":false,"given":"Ay\u015fe Nur","family":"Do\u011fan","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Nephrology, Hypertension, and Renal Transplantation University of Florida College of Medicine  Gainesville Florida USA"},{"name":"Department of 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