{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:08:25Z","timestamp":1784290105209,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study evaluated the effect of aging on bone regeneration in mandibular extraction sockets. Male Sprague\u2013Dawley rats were divided into three age groups: 2\u2010month\u2010old (2\u00a0M,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a06), 10\u2010month\u2010old (10\u00a0M,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a06), and 18\u2010month\u2010old (18\u00a0M,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a05). Two weeks post\u2010extraction, comprehensive analyses were performed using micro\u2010computed tomography (\n                    <jats:italic>\u00b5<\/jats:italic>\n                    \u2010CT), serum bone turnover markers, histology, and immunohistochemistry. Notably, to ensure accurate volumetric assessment, a specific tooth\u2010based region of interest utilizing the extracted tooth was employed for precise\n                    <jats:italic>\u00b5<\/jats:italic>\n                    \u2010CT analysis. Radiologically, the 18\u00a0M group exhibited significantly reduced bone volume and trabecular thickness compared to the younger groups. Serum analysis revealed that younger rats maintained higher baseline metabolic activity, specifically regarding osteocalcin and CTX\u2010I, and exhibited a distinct post\u2010extraction tartrate\u2010resistant acid phosphatase 5b response. Histological and immunohistochemical findings corroborated these results; the 10\u00a0M group demonstrated the most favorable bone regeneration with maximal alkaline phosphatase expression filling the socket, whereas the 18\u00a0M group exhibited compromised healing characterized by empty sockets and inflammatory cell accumulation. In conclusion, aging significantly deteriorates the biological healing capacity of alveolar bone. Although younger animals exhibit robust metabolic responses and bone formation, senescent rats show a marked decline in regenerative potential, emphasizing the need for age\u2010specific considerations in dental rehabilitation.\n                  <\/jats:p>","DOI":"10.1111\/eos.70099","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:30:45Z","timestamp":1777559445000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of aging on healing of mandibular tooth extraction socket in a rat model"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5699-3414","authenticated-orcid":false,"given":"Kyung Su","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery School of Dentistry Jeonbuk National University  Jeonju Republic of Korea"},{"name":"Research Institute of Clinical Medicine of Jeonbuk 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