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Oral cGVHD manifests mucosal inflammation, salivary gland dysfunction, and fibrosis, all of which substantially impair patients\u2019 quality of life. To date, research efforts have predominantly focused on clinical investigations, with relatively limited exploration of animal models for in vivo studies, despite animal models playing a pivotal role in deciphering the pathobiology of cGVHD and developing therapeutic strategies. This review synthesizes the classification, modeling methodologies, and pathological characteristics of systemic GVHD animal models, with particular emphasis on the phenotypic manifestations of oral involvement. By critically assessing the strengths and limitations of murine, rat, canine, and nonhuman primate models, this article aims to provide a comprehensive narrative framework for selecting appropriate animal models in future in vivo studies of oral cGVHD.<\/jats:p>","DOI":"10.1111\/eos.70110","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T06:00:49Z","timestamp":1779775249000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Animal models of chronic graft\u2010versus\u2010host disease with oral involvement: A review"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2406-3540","authenticated-orcid":false,"given":"Shuqian","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Periodontal and Oral Medicine College of Stomatology Guangxi Medical University  Nanning P. R. 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