{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T12:15:47Z","timestamp":1788005747416,"version":"build-2784847793"},"reference-count":78,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This systematic review investigated the osteogenic effects of platelet concentrate (PRF\/PRP) when combined with non\u2010autogenous graft materials in sinus lift procedures. Key characteristics assessed included platelet concentration, total platelet dose, leukocyte content, and fibrin\u2010network structure. A comprehensive search of EMBASE OvidSP, PubMed, and the Cochrane Library was conducted in April 2026, resulting in the inclusion of 25 articles. Studies were broadly categorized according to whether they reported enhanced osteogenic outcomes or not: positive studies (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a015) and negative studies (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a010). A key finding is that positive studies used a higher total platelet dose than negative studies (8.02\u00a0\u00d7\u00a010\n                    <jats:sup>9<\/jats:sup>\n                    vs. 3.67\u00a0\u00d7\u00a010\n                    <jats:sup>9<\/jats:sup>\n                    ). A subgroup meta\u2010analysis of eight randomized controlled trials (RCTs) found that the five high\u2010dose studies, using approx. \u226510\u00a0\u00d7\u00a010\n                    <jats:sup>9<\/jats:sup>\n                    platelets, demonstrated a significant increase in new bone formation (effect size: 1.04;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.01). In contrast, the three low\u2010dose studies showed a modest but nonsignificant effect (effect size: 0.49;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.355). However, the difference between the two subgroups was not statistically significant. Available evidence suggests that higher platelet doses, particularly around \u226510\u00a0\u00d7\u00a010\n                    <jats:sup>9<\/jats:sup>\n                    platelets, may be associated with more favorable osteogenic outcomes. However, this dose should not be interpreted as a clinically validated threshold.\n                  <\/jats:p>","DOI":"10.1111\/eos.70136","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T11:15:56Z","timestamp":1788002156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Platelet concentrates in sinus augmentation: The impact of platelet dose and biological characteristics\u2014\n                    <i>A systematic review and meta\u2010analysis<\/i>"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6414-2241","authenticated-orcid":false,"given":"Olav Kansgar","family":"Straum","sequence":"first","affiliation":[{"name":"Department of Education Faculty of Humanities Social Sciences and Education UiT The Arctic University of Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7973-1002","authenticated-orcid":false,"given":"Hans Thomas","family":"Brox","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Division of Oral and Maxillofacial Surgery University Hospital North of Norway  Troms\u00f8 Norway"},{"name":"The Public Dental Health Service Competence Center of Northern Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3624-5812","authenticated-orcid":false,"given":"Juliane","family":"Hesse","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Division of Oral and Maxillofacial Surgery University Hospital North of Norway  Troms\u00f8 Norway"},{"name":"The Public Dental Health Service Competence Center of Northern Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2036-8702","authenticated-orcid":false,"given":"Andreas J\u00f6rn","family":"Schmalfuss","sequence":"additional","affiliation":[{"name":"The Public Dental Health Service Competence Center of Northern Norway  Troms\u00f8 Norway"},{"name":"Department of Clinical Dentistry Faculty of Health Sciences UiT Arctic University of Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2388-4251","authenticated-orcid":false,"given":"Erlend","family":"Bugge","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Faculty of Medical Sciences UiT The Arctic University of Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"issue":"7","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.jcms.2025.03.009","article-title":"The impact of platelet concentrates in maxillary sinus lifts: a systematic review and meta\u2010analysis","volume":"53","author":"Zhao Z","year":"2025","journal-title":"J Craniomaxillofac Surg"},{"issue":"2","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/00001665-200503000-00015","article-title":"Evaluation of the adjunctive benefits of platelet\u2010rich plasma in subantral sinus augmentation","volume":"16","author":"Kassolis JD","year":"2005","journal-title":"J Craniofac Surg"},{"issue":"4","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.blre.2009.04.001","article-title":"Platelet alpha\u2010granules: basic biology and clinical 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Systematic review and meta\u2010analysis","volume":"49","author":"Abdalla RIB","year":"2018","journal-title":"Quintessence Int"},{"key":"e_1_2_9_15_1","article-title":"Effectiveness of platelet\u2010rich fibrin as an adjunctive material to bone graft in maxillary sinus augmentation: a meta\u2010analysis of randomized controlled trails","volume":"2019","author":"Liu R","year":"2019","journal-title":"Biomed Res Int"},{"issue":"2","key":"e_1_2_9_16_1","first-page":"133","article-title":"Effect of autologous concentrated growth factor in regenerative dentistry: a systematic review and meta\u2010analysis","volume":"11","author":"Alshirah AA","year":"2026","journal-title":"JDR Clin Trans Res"},{"issue":"2","key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00264-016-3342-9","article-title":"Platelet\u2010rich plasma for the treatment of bone defects: from pre\u2010clinical rational to evidence in the clinical practice. 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