{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:01:33Z","timestamp":1790766093210,"version":"4.1.0"},"reference-count":128,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["409294\/2018\u20107"],"award-info":[{"award-number":["409294\/2018\u20107"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sj\u00f6gren's disease (SjD) bears the name of the Swedish ophthalmologist Henrik Sj\u00f6gren. His 1933 doctoral thesis on\n                    <jats:italic>keratoconjunctivitis sicca<\/jats:italic>\n                    ignited interest, yet much remains under debate. SjD is an autoimmune disorder that primarily affects the exocrine glands, particularly the salivary and lacrimal glands, leading to a dryness of the eyes and mouth. Diagnostic criteria have evolved significantly, with over 10 classification criteria proposed since 1965. From its inception, SjD was often overshadowed by other rheumatic diseases, struggling for recognition as a distinct autoimmune entity. Early research in the 1960s and 1970s led to inconsistent nomenclature for autoantibodies, further complicating understanding. Although Sj\u00f6gren studied biopsies early on, standardized approaches to biopsy sites and histological findings took considerable time to establish. Recent advancements, such as the introduction of salivary gland ultrasound as a non\u2010invasive diagnostic tool, have offered new avenues for investigation. However, challenges persist in accurately assessing disease activity due to the wide range of manifestations. This narrative and historical review explores the evolution of Sj\u00f6gren's syndrome as a distinct disease, tracing its history from initial descriptions to contemporary developments.\n                  <\/jats:p>","DOI":"10.1111\/eos.70147","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:17:09Z","timestamp":1790763429000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Charting the course of Sj\u00f6gren's disease: A historical analysis of scientific progress"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8103-0532","authenticated-orcid":false,"given":"Diego Ust\u00e1rroz","family":"Cantali","sequence":"first","affiliation":[{"name":"Rheumatology Unit S\u00e3o Lucas Hospital Pontifical Catholic University of Rio Grande Do Sul  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9196-7422","authenticated-orcid":false,"given":"Fabiola Reis","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Internal Medicine Department Ribeirao Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9371-5886","authenticated-orcid":false,"given":"Denise Cantarelli","family":"Machado","sequence":"additional","affiliation":[{"name":"Molecular Biology and Immunology Laboratory Brain Institute (BraIns) Pontifical Catholic University of Rio Grande do Sul  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2957-1352","authenticated-orcid":false,"given":"Mois\u00e9s Evandro","family":"Bauer","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology School of Health and Life Sciences Pontifical Catholic University of Rio Grande do Sul (PUCRS)  Porto Alegre Rio Grande do Sul Brazil"},{"name":"National Institute of Science and Technology\u2014Neuroimmunomodulation (INCT\u2014NIM) Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)  Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2019.102448","article-title":"The prevalence of 78 autoimmune diseases in Catalonia (MASCAT\u2010PADRIS Big Data Project)","volume":"19","author":"Sis\u00f3\u2010Almirall A","year":"2020","journal-title":"Autoimmun Rev"},{"issue":"7","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41584-025-01268-z","article-title":"2023 International Rome consensus for the nomenclature of Sj\u00f6gren disease","volume":"21","author":"Ramos\u2010Casals M","year":"2025","journal-title":"Nat Rev Rheumatol"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2020.102590","article-title":"Early diagnosis and treatment for Sj\u00f6gren's syndrome: current challenges, redefined disease stages and future prospects","volume":"117","author":"Wang B","year":"2021","journal-title":"J Autoimmun"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.47","article-title":"Sj\u00f6gren syndrome","volume":"2","author":"Brito\u2010Zer\u00f3n P","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"e_1_2_11_6_1","first-page":"165","article-title":"Praparate zu dem Vortag \u00fcber Entstehung der Netzhautablosung und \u00fcber verscheiedene Hornhautaffektionen","volume":"14","author":"Leber T","year":"1882","journal-title":"Klin Monatsblatter Augenheilkd"},{"key":"e_1_2_11_7_1","first-page":"176","article-title":"On \u201cdry mouth\u201d, or suppression of the salivary and buccal secretions","volume":"21","author":"Hadden WB","year":"1888","journal-title":"Trans Clin Soc Lond"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0140-6736(00)30178-7","article-title":"\u201cXerostomia\u201d\u2014a term suggested for the affection known as dry mouth","volume":"133","author":"Hutchinson J","year":"1889","journal-title":"Lancet"},{"key":"e_1_2_11_9_1","volume-title":"Beitr\u00e4ge zur Chirurgie. 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