{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:21:24Z","timestamp":1790162484319,"version":"4.1.0"},"reference-count":68,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Idiopathic generalized epilepsy (\n                      <jats:styled-content style=\"fixed-case\">IGE<\/jats:styled-content>\n                      ) resistant to treatment is common, but its neuronal correlates are not entirely understood. Therefore, the aim of this study was to examine resting\u2010state default mode network (\n                      <jats:styled-content style=\"fixed-case\">DMN<\/jats:styled-content>\n                      ) functional connectivity in patients with treatment\u2010resistant\n                      <jats:styled-content style=\"fixed-case\">IGE<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Treatment resistance was defined as continuing seizures despite an adequate dose of valproic acid (valproate,\n                      <jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content>\n                      ). Data from 60 epilepsy patients and 38 healthy controls who underwent simultaneous electroencephalography (\n                      <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>\n                      ) and resting\u2010state functional magnetic resonance imaging (\n                      <jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content>\n                      ) were included (\n                      <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content>\n                      ). Independent component analysis (\n                      <jats:styled-content style=\"fixed-case\">ICA<\/jats:styled-content>\n                      ) and dual regression were used to quantify\n                      <jats:styled-content style=\"fixed-case\">DMN<\/jats:styled-content>\n                      connectivity. Confirmatory analysis using seed\u2010based voxel correlation was performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Findings<\/jats:title>\n                    <jats:p>\n                      There was a significant reduction of\n                      <jats:styled-content style=\"fixed-case\">DMN<\/jats:styled-content>\n                      connectivity in patients with treatment\u2010resistant epilepsy when compared to patients who were treatment responsive and healthy controls. Connectivity was negatively correlated with duration of epilepsy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>\n                      Our findings in this large sample of patients with\n                      <jats:styled-content style=\"fixed-case\">IGE<\/jats:styled-content>\n                      indicate the presence of reduced\n                      <jats:styled-content style=\"fixed-case\">DMN<\/jats:styled-content>\n                      connectivity in\n                      <jats:styled-content style=\"fixed-case\">IGE<\/jats:styled-content>\n                      and show that connectivity is further reduced in treatment\u2010resistant epilepsy.\n                      <jats:styled-content style=\"fixed-case\">DMN<\/jats:styled-content>\n                      connectivity may be useful as a biomarker for treatment resistance.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.12057","type":"journal-article","created":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T09:19:23Z","timestamp":1357550363000},"page":"461-470","source":"Crossref","is-referenced-by-count":82,"title":["Reduced default mode network connectivity in treatment\u2010resistant idiopathic generalized epilepsy"],"prefix":"10.1111","volume":"54","author":[{"given":"Benjamin P.","family":"Kay","sequence":"first","affiliation":[{"name":"Neuroscience Graduate Program University of Cincinnati Cincinnati Ohio U.S.A"},{"name":"Pediatric Neuroimaging Research Consortium Cincinnati Children's Hospital Medical Center Cincinnati Ohio U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"DiFrancesco","sequence":"additional","affiliation":[{"name":"Pediatric Neuroimaging Research Consortium Cincinnati Children's Hospital Medical Center Cincinnati Ohio U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Privitera","sequence":"additional","affiliation":[{"name":"Department of Neurology and the Cincinnati Epilepsy Center University of Cincinnati Cincinnati Ohio U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Gotman","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott K.","family":"Holland","sequence":"additional","affiliation":[{"name":"Pediatric Neuroimaging Research Consortium Cincinnati Children's Hospital Medical Center Cincinnati Ohio U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy P.","family":"Szaflarski","sequence":"additional","affiliation":[{"name":"Pediatric Neuroimaging Research Consortium Cincinnati Children's Hospital Medical Center Cincinnati Ohio U.S.A"},{"name":"Department of Neurology and the Cincinnati Epilepsy Center University of Cincinnati Cincinnati Ohio U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh136"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0599"},{"key":"e_1_2_7_4_1","unstructured":"AnderssonJLR JenkinsonM SmithS. 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