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Data on treatment are insufficient and clinical practice still relies heavily on individual experience. In this article we review evidence\u2010based treatment strategies for primary major anxiety disorders and adapt them to the specific needs of patients with epilepsy. In panic disorder, a combined approach, namely serotonin\u2010reuptake inhibitors (<jats:styled-content style=\"fixed-case\">SSRI<\/jats:styled-content>s) and cognitive behavioral therapy (<jats:styled-content style=\"fixed-case\">CBT<\/jats:styled-content>) is always indicated during the acute phase. Long\u2010term maintenance treatment may include combined therapy or <jats:styled-content style=\"fixed-case\">CBT<\/jats:styled-content> alone depending on individual cases. For generalized anxiety disorders pregabalin has to be considered first choice for short\u2010term and long\u2010term treatment. In social anxiety disorder and posttraumatic stress disorder <jats:styled-content style=\"fixed-case\">SSRI<\/jats:styled-content>s, in particular sertraline and paroxetine, can be safely used. Obsessive\u2010compulsive disorder represents a serious condition that needs to be approached in a psychiatric setting. <jats:styled-content style=\"fixed-case\">CBT<\/jats:styled-content> should be considered as the first choice in patients with epilepsy. If drug treatment is needed, epileptologists have to be aware that high\u2010dose antidepressants are appropriate and that <jats:styled-content style=\"fixed-case\">SSRI<\/jats:styled-content>s, in particular sertraline, should be considered first choice. In these patients, careful clinical monitoring is indicated, in selected cases, for potential seizure precipitation and side effects due to pharmacodynamics interactions.<\/jats:p>","DOI":"10.1111\/epi.12101","type":"journal-article","created":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T05:44:18Z","timestamp":1362462258000},"page":"13-18","source":"Crossref","is-referenced-by-count":68,"title":["Treatment of anxiety disorders in epilepsy: An evidence\u2010based approach"],"prefix":"10.1111","volume":"54","author":[{"given":"Marco","family":"Mula","sequence":"first","affiliation":[{"name":"Division of Neurology, Trinity Hospital  Borgomanero Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1991.tb03176.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebmh.9.2.43"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2002.02255.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/15622970601110273"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.7.7.769"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2008.04.005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2009.50"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.179.1.23"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199503000-00006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2009.12.009"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.10.1005"},{"issue":"3","key":"e_1_2_7_13_1","first-page":"359","article-title":"Theories on anxiety in Freud and Melanie Klein. 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