{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:23Z","timestamp":1787014163509,"version":"build-2736575974"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,1,29]],"date-time":"2013-01-29T00:00:00Z","timestamp":1359417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Lacosamide, a recently introduced antiepileptic drug, acts by enhancing the slow inactivation of voltage\u2010dependent sodium channels. Cardiac conduction disturbances, namely atrial fibrillation and atrioventricular block, have been reported in patients with epilepsy. We report a patient with drug\u2010resistant focal epilepsy who developed asymptomatic sinus node dysfunction following lacosamide use, which resolved on stopping lacosamide. This is the first report of sinus node dysfunction associated with lacosamide therapy.<\/jats:p>","DOI":"10.1111\/epi.12108","type":"journal-article","created":{"date-parts":[[2013,1,29]],"date-time":"2013-01-29T10:58:32Z","timestamp":1359457112000},"source":"Crossref","is-referenced-by-count":45,"title":["Sinus node dysfunction: An adverse effect of lacosamide"],"prefix":"10.1111","volume":"54","author":[{"given":"Suganthi","family":"Chinnasami","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy National Hospital for Neurology and Neurosurgery London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaturbhuj","family":"Rathore","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy National Hospital for Neurology and Neurosurgery London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy National Hospital for Neurology and Neurosurgery London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01188.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02496.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2010.04.043"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1001\/archinte.1992.00400130184025","article-title":"Carbamazepine induced cardiac dysfunction. Characterization of two distinct clinical syndromes","volume":"152","author":"Kasarskis EJ","year":"1992","journal-title":"Arch Intern Med"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S5189"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2011.02.006"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03212.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/11587550-000000000-00000"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.01.322"},{"key":"e_1_2_6_11_1","volume-title":"Vimpat prescribing information","author":"UCB Pharma","year":"2009"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e318196d2b6"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.12108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.12108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T00:05:23Z","timestamp":1698624323000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.12108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,29]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/epi.12108"],"URL":"https:\/\/doi.org\/10.1111\/epi.12108","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,29]]}}}