{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:41:52Z","timestamp":1790293312631,"version":"4.1.0"},"reference-count":149,"publisher":"Wiley","issue":"s4","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Many symptoms of neurologic or psychiatric illness\u2014such as cognitive impairment, depression, anxiety, attention deficits, and migraine\u2014occur more frequently in people with epilepsy than in the general population. These diverse comorbidities present an underappreciated problem for people with epilepsy and their caregivers because they decrease quality of life, complicate treatment, and increase mortality. In fact, it has been suggested that comorbidities can have a greater effect on quality of life in people with epilepsy than the seizures themselves. There is increasing recognition of the frequency and impact of cognitive and behavioral comorbidities of epilepsy, highlighted in the 2012\n                    <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\n                    nstitute of\n                    <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\n                    edicine report on epilepsy. Comorbidities have also been acknowledged, as a National Institutes of Health (\n                    <jats:styled-content style=\"fixed-case\">NIH<\/jats:styled-content>\n                    )\n                    <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                    enchmark area for research in epilepsy. However, relatively little progress has been made in developing new therapies directed specifically at comorbidities. On the other hand, there have been many advances in understanding underlying mechanisms. These advances have made it possible to identify novel targets for therapy and prevention. As part of the\n                    <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\n                    nternational\n                    <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\n                    eague\n                    <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                    gainst\n                    <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\n                    pilepsy\/\n                    <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                    merican\n                    <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\n                    pilepsy\n                    <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                    ociety workshop on preclinical therapy development for epilepsy, our working group considered the current state of understanding related to terminology, models, and strategies for therapy development for the comorbidities of epilepsy. Herein we summarize our findings and suggest ways to accelerate development of new therapies. We also consider important issues to improve research including those related to methodology, nonpharmacologic therapies, biomarkers, and infrastructure.\n                  <\/jats:p>","DOI":"10.1111\/epi.12298","type":"journal-article","created":{"date-parts":[[2013,8,2]],"date-time":"2013-08-02T06:31:48Z","timestamp":1375425108000},"page":"44-60","source":"Crossref","is-referenced-by-count":148,"title":["Issues related to symptomatic and disease\u2010modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy"],"prefix":"10.1111","volume":"54","author":[{"given":"Amy R.","family":"Brooks\u2010Kayal","sequence":"first","affiliation":[{"name":"Departments of Pediatrics, Neurology and Pharmaceutical Sciences University of Colorado Schools of Medicine and Pharmacy Children's Hospital Colorado Aurora Colorado U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin G.","family":"Bath","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Brown University Providence Rhode Island U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne T.","family":"Berg","sequence":"additional","affiliation":[{"name":"Ann &amp; Robert H Lurie Children's Hospital of Chicago Chicago Illinois U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristea S.","family":"Galanopoulou","sequence":"additional","affiliation":[{"name":"Saul R. Korey Department of Neurology Dominick P. 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