{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:18:27Z","timestamp":1773285507598,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Refractory status epilepticus (<jats:styled-content style=\"fixed-case\">RSE<\/jats:styled-content>) is a life\u2010threatening emergency, demonstrating, by definition, significant pharmacoresistance. We describe five cases of pediatric <jats:styled-content style=\"fixed-case\">RSE<\/jats:styled-content> treated with mild hypothermia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective chart review was performed of records of children who received hypothermia for <jats:styled-content style=\"fixed-case\">RSE<\/jats:styled-content> at two tertiary\u2010care pediatric hospitals between 2009 and 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Findings<\/jats:title><jats:p>Five children with <jats:styled-content style=\"fixed-case\">RSE<\/jats:styled-content> received mild hypothermia (32\u201335\u00b0C). Hypothermia reduced seizure burden during and after treatment in all cases. Prior to initiation of hypothermia, four children (80%) received pentobarbital infusions to treat <jats:styled-content style=\"fixed-case\">RSE<\/jats:styled-content>, but relapsed after pentobarbital discontinuation. No child relapsed after treatment with hypothermia. One child died after redirection of care. Remaining four children were discharged.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This is the largest pediatric case series reporting treatment of <jats:styled-content style=\"fixed-case\">RSE<\/jats:styled-content> with mild hypothermia. Hypothermia decreased seizure burden during and after pediatric <jats:styled-content style=\"fixed-case\">RSE<\/jats:styled-content> and may prevent <jats:styled-content style=\"fixed-case\">RSE<\/jats:styled-content> relapse.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.12331","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T22:23:56Z","timestamp":1375395836000},"page":"1586-1594","source":"Crossref","is-referenced-by-count":65,"title":["Hypothermia for pediatric refractory status epilepticus"],"prefix":"10.1111","volume":"54","author":[{"given":"Kristin","family":"Guilliams","sequence":"first","affiliation":[{"name":"Division of Pediatric and Developmental Neurology Department of Neurology Washington University in St. Louis St. Louis Missouri U.S.A"},{"name":"Division of Critical Care Medicine Department of Pediatrics Washington University in St. Louis St. Louis Missouri 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