{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:19:03Z","timestamp":1791051543032,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T00:00:00Z","timestamp":1377734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To describe the clinical characteristics and outcomes of individuals with neurofibromatosis type 1 (<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1) and seizures in the largest cohort reported to date.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cross\u2010sectional review of 536 individuals with <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 was performed, and clinical data from 51 individuals with a history of at least one seizure were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Findings<\/jats:title><jats:p>In individuals with <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1, 9.5% had a history of at least one unprovoked seizure, and 6.5% had documented epilepsy. Individuals with seizures were more likely to have inherited <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 from their mother (p\u00a0=\u00a00.001). Focal seizures were the most common type, occurring in 57% of individuals, although generalized seizures, specific electroclinical syndromes, and the presence of multiple seizure types were also noted. Moreover, in 21% of individuals with a previously unremarkable magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) study, neuroimaging at seizure onset revealed a new structural abnormality. In this population, 77% of individuals required multiple antiepileptic drugs (<jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s), and some required epilepsy surgery, with the best results following temporal lobe glioma resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Compared to the general population, seizures are more common in individuals with <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1, where they are often focal and related to an intracranial neoplasm. These observations suggest that all individuals with <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 and a new seizure should undergo <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> despite previous normal neuroimaging. Individuals with seizures and <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 typically require more aggressive therapy than those without <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 and should be considered for epilepsy surgery when appropriate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.12348","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T12:32:49Z","timestamp":1377779569000},"page":"1810-1814","source":"Crossref","is-referenced-by-count":87,"title":["Epilepsy in individuals with neurofibromatosis type 1"],"prefix":"10.1111","volume":"54","author":[{"given":"Adam P.","family":"Ostendorf","sequence":"first","affiliation":[{"name":"Department of Neurology Washington University School of Medicine St. Louis Missouri U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Gutmann","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University School of Medicine St. Louis Missouri U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith L. 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