{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:56:44Z","timestamp":1787749004418,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,9,30]],"date-time":"2013-09-30T00:00:00Z","timestamp":1380499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"IGA","award":["NT13357-4\/2012"],"award-info":[{"award-number":["NT13357-4\/2012"]}]},{"name":"MH CZ - DRO"},{"name":"University Hospital Motol","award":["00064203"],"award-info":[{"award-number":["00064203"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Variable predictors of postsurgical seizure outcome have been reported in children with tuberous sclerosis complex (\n                      <jats:styled-content style=\"fixed-case\">TSC<\/jats:styled-content>\n                      ). We analyzed a large surgical series of pediatric\n                      <jats:styled-content style=\"fixed-case\">TSC<\/jats:styled-content>\n                      patients in order to identify prognostic factors crucial for selection of subjects for epilepsy surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010three children with\n                      <jats:styled-content style=\"fixed-case\">TSC<\/jats:styled-content>\n                      who underwent excisional epilepsy surgery at\n                      <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\n                      iami\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      hildren's\n                      <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\n                      ospital were retrospectively reviewed. A total of 29 clinical, neuropsychological, electroencephalography (\n                      <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>\n                      ), magnetic resonance imaging (\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      ), and surgical variables were analyzed and related to seizure outcomes. Univariate\n                      <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                      arnard's exact test,\n                      <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>\n                      ilcoxon's rank\u2010sum test, and multivariate statistical\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      ox's model were used to examine the significance of associations between the variables and seizure outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Findings<\/jats:title>\n                    <jats:p>\n                      Eighteen patients (55%) have been seizure\u2010free 2\u00a0years after (final) surgery; postoperative complications occurred in five subjects (15%). Complete removal of epileptogenic tissue detected by both\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      and intracranial\n                      <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>\n                      , regional scalp interictal\n                      <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>\n                      patterns, and agreement of interictal and ictal\n                      <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>\n                      localization were the most powerful predictors of seizure\u2010free outcome. Other significant predictors included occurrence of regional scalp ictal\n                      <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>\n                      patterns, fewer brain regions affected by tubers, presence of preoperative hemiparesis, and one\u2010stage surgery. Remaining factors such as age at seizure onset, incidence of infantile spasms or other seizure types, duration of epilepsy, seizure frequency, mental retardation, as well as types and extent of resections did not influence outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>\n                      Perioperative features rather than preoperative variables are the most important determinants of postsurgical seizure outcome in patients with\n                      <jats:styled-content style=\"fixed-case\">TSC<\/jats:styled-content>\n                      . Our findings may assist in the surgical management of these patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.12371","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T21:42:47Z","timestamp":1381527767000},"page":"1913-1921","source":"Crossref","is-referenced-by-count":57,"title":["Predictors of seizure\u2010free outcome after epilepsy surgery for pediatric tuberous sclerosis complex"],"prefix":"10.1111","volume":"54","author":[{"given":"Pavel","family":"Krsek","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology 2nd Faculty of Medicine Motol University Hospital Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Jahodova","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology 2nd Faculty of Medicine Motol University Hospital Charles University Prague Czech 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