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Twelve hours post\u2010\n HS<\/jats:styled-content>\n , we assessed m\n TOR<\/jats:styled-content>\n activation marker phosphorylated p70\u2010\n S<\/jats:styled-content>\n 6 kinase (p\u2010p70\n S<\/jats:styled-content>\n 6\n K<\/jats:styled-content>\n ) in hippocampus and cortex of vehicle (\n HS<\/jats:styled-content>\n \u00a0+\u00a0\n V<\/jats:styled-content>\n ) or\n NBQX<\/jats:styled-content>\n \u2010treated post\u2010\n HS<\/jats:styled-content>\n rats (\n HS<\/jats:styled-content>\n \u00a0+\u00a0\n N<\/jats:styled-content>\n ) versus littermate controls (\n C<\/jats:styled-content>\n \u00a0+\u00a0\n V<\/jats:styled-content>\n ). Spontaneous seizure activity was compared between groups by epidural cortical electroencephalography (\n EEG<\/jats:styled-content>\n ) at\n P<\/jats:styled-content>\n 70\u2013100. Aberrant mossy fiber sprouting was measured using\n T<\/jats:styled-content>\n imm staining. Finally, we assessed behavior between\n P<\/jats:styled-content>\n 30 and P38.\n <\/jats:p>\n <\/jats:sec>\n \n Key Findings<\/jats:title>\n \n Postseizure\n NBQX<\/jats:styled-content>\n treatment significantly attenuated seizure\u2010induced increases in p\u2010\n p<\/jats:styled-content>\n 70\n S<\/jats:styled-content>\n 6\n K<\/jats:styled-content>\n in the hippocampus (p\u00a0<\u00a00.01) and cortex (p\u00a0<\u00a00.001). Although spontaneous recurrent seizures increased in adulthood in\n HS<\/jats:styled-content>\n \u00a0+\u00a0\n V<\/jats:styled-content>\n rats compared to controls (3.22\u00a0\u00b1\u00a01\u00a0seizures\/h; p\u00a0=\u00a00.03),\n NBQX<\/jats:styled-content>\n significantly attenuated later\u2010life seizures (0.14\u00a0\u00b1\u00a00.1\u00a0seizures\/h; p\u00a0=\u00a00.046).\n HS<\/jats:styled-content>\n \u00a0+\u00a0\n N<\/jats:styled-content>\n rats showed less aberrant mossy fiber sprouting (115\u00a0\u00b1\u00a08.0%) than vehicle\u2010treated post\u2010\n HS<\/jats:styled-content>\n rats (174\u00a0\u00b1\u00a010%, p\u00a0=\u00a00.004), compared to controls (normalized to 100%). Finally,\n NBQX<\/jats:styled-content>\n treatment prevented alterations in later\u2010life social behavior; post\u2010\n HS<\/jats:styled-content>\n rats showed significantly decreased preference for a novel over a familiar rat (71.0\u00a0\u00b1\u00a012\u00a0s) compared to controls (99.0\u00a0\u00b1\u00a015.6\u00a0s; p\u00a0<\u00a00.01), whereas\n HS<\/jats:styled-content>\n \u00a0+\u00a0\n N<\/jats:styled-content>\n rats showed social novelty preference similar to controls (114.3\u00a0\u00b1\u00a014.1\u00a0s).\n <\/jats:p>\n <\/jats:sec>\n \n Significance<\/jats:title>\n \n Brief\n NBQX<\/jats:styled-content>\n administration during the 48\u00a0h postseizure in\n P<\/jats:styled-content>\n 10\n L<\/jats:styled-content>\n ong\u2010\n E<\/jats:styled-content>\n vans rats suppresses transient m\n TOR<\/jats:styled-content>\n pathway activation and attenuates spontaneous recurrent seizures, social preference deficits, and mossy fiber sprouting observed in vehicle\u2010treated adult rats after early life seizures. These results suggest that acute\n AMPAR<\/jats:styled-content>\n antagonist treatment during the latent period immediately following neonatal\n HS<\/jats:styled-content>\n can modify seizure\u2010induced activation of m\n TOR<\/jats:styled-content>\n , reduce the frequency of later\u2010life seizures, and protect against\n CA<\/jats:styled-content>\n 3 mossy fiber sprouting and autistic\u2010like social deficits.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/epi.12378","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T21:40:52Z","timestamp":1381527652000},"page":"1922-1932","source":"Crossref","is-referenced-by-count":67,"title":["AMPA<\/scp>\n Receptor antagonist\n NBQX<\/scp>\n attenuates later\u2010life epileptic seizures and autistic\u2010like social deficits following neonatal seizures"],"prefix":"10.1111","volume":"54","author":[{"given":"Jocelyn J.","family":"Lippman\u2010Bell","sequence":"first","affiliation":[{"name":"Department of Neurology Children's Hospital Boston and Harvard Medical School Boston Massachusetts U.S.A"},{"name":"Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay N.","family":"Rakhade","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's Hospital Boston and Harvard Medical School Boston Massachusetts U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's Hospital Boston and Harvard Medical School Boston Massachusetts U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makram","family":"Obeid","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's Hospital Boston and Harvard Medical School Boston Massachusetts U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele 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