{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:23:46Z","timestamp":1750033426425,"version":"3.37.3"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T00:00:00Z","timestamp":1382054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Use of antiepileptic drugs (<jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s) in pregnant women with epilepsy (<jats:styled-content style=\"fixed-case\">WWE<\/jats:styled-content>) is associated with an increased risk of major congenital malformations (<jats:styled-content style=\"fixed-case\">MCM<\/jats:styled-content>). Previous studies have suggested that <jats:styled-content style=\"fixed-case\">WWE<\/jats:styled-content> who had a malformation in their index pregnancy were at an increased risk of recurrence in future pregnancies. We aimed to assess the risk of recurrence of <jats:styled-content style=\"fixed-case\">MCM<\/jats:styled-content> in 1,616 <jats:styled-content style=\"fixed-case\">WWE<\/jats:styled-content> from Kerala Registry of Epilepsy and Pregnancy. The pregnancy outcome of women (n\u00a0=\u00a0246) with two prospective pregnancies in the registry were analyzed. They had partial seizures with or without generalization (57.3%) or generalized seizures (42.7%). Polytherapy was used in 26.4% (index pregnancy) and 23.6% (follow\u2010up pregnancy). The mean dosage of <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> for valproate was 498\u00a0mg\/day and carbamazepine was 555\u00a0mg\/day. The malformation rate in the index pregnancy was 8.5% (21\/246) and in the follow\u2010up pregnancy was 8.9% (22\/246) with only one recurrence. There was no increased risk of <jats:styled-content style=\"fixed-case\">MCM<\/jats:styled-content> in follow\u2010up pregnancy for those who had <jats:styled-content style=\"fixed-case\">MCM<\/jats:styled-content> in the index pregnancy (p\u00a0=\u00a00.70; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.49; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.06\u20133.80). The use of any specific drug, continuation of the same drug or a change in drug therapy between two pregnancies did not alter the recurrence risk.<\/jats:p>","DOI":"10.1111\/epi.12411","type":"journal-article","created":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T17:18:42Z","timestamp":1382116722000},"source":"Crossref","is-referenced-by-count":8,"title":["Malformation in index pregnancy in women with epilepsy is not followed by recurrence in subsequent pregnancy"],"prefix":"10.1111","volume":"54","author":[{"given":"Shehanaaz","family":"Begum","sequence":"first","affiliation":[{"name":"Kerala Registry of Epilepsy and Pregnancy Sree Chitra Tirunal Institute for Medical Sciences and Technology Trivandrum Kerala State India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sankara P.","family":"Sarma","sequence":"additional","affiliation":[{"name":"Kerala Registry of Epilepsy and Pregnancy Sree Chitra Tirunal Institute for Medical Sciences and Technology Trivandrum Kerala State India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeev V.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Kerala Registry of Epilepsy and Pregnancy Sree Chitra Tirunal Institute for Medical Sciences and Technology Trivandrum Kerala State India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2001.11201.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.S3.957"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199507203330305"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000195888.51845.80"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199407073310101"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2008.04.022"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990219)82:5<423::AID-AJMG12>3.0.CO;2-C"},{"key":"e_1_2_6_10_1","first-page":"60","article-title":"Pregnancy in women with epilepsy: preliminary results of Kerala Registry of Epilepsy and Pregnancy","volume":"49","author":"Thomas SV","year":"2001","journal-title":"Neurol India"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03439.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70107-7"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01412.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03625.x"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.12411","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.12411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T22:00:38Z","timestamp":1696284038000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.12411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,18]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/epi.12411"],"URL":"https:\/\/doi.org\/10.1111\/epi.12411","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"type":"print","value":"0013-9580"},{"type":"electronic","value":"1528-1167"}],"subject":[],"published":{"date-parts":[[2013,10,18]]}}}