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This review summarized neuroimaging studies that have tried to describe specific fingerprints of brain activation in<jats:styled-content style=\"fixed-case\">EE<\/jats:styled-content>. Although the epileptic activity can be generated individually in different brain regions, it seems likely that the activity propagates in a syndrome\u2010specific way. In some<jats:styled-content style=\"fixed-case\">EE<\/jats:styled-content>s, the epileptiform discharges were associated with an interruption of activity in the default mode network. In another<jats:styled-content style=\"fixed-case\">EE<\/jats:styled-content>, other mechanisms seem to underlie cognitive disability associated with epileptic activity, for example, abnormal connectivity pattern or interfering activity in the thalamocortical network. Further neuroimaging studies are needed to investigate the short\u2010term and long\u2010term impact of epileptic activity on cognition and development.<\/jats:p>","DOI":"10.1111\/epi.12420","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T15:44:25Z","timestamp":1384357465000},"page":"27-33","source":"Crossref","is-referenced-by-count":13,"title":["Functional neuroimaging in epileptic encephalopathies"],"prefix":"10.1111","volume":"54","author":[{"given":"Michael","family":"Siniatchkin","sequence":"first","affiliation":[{"name":"Clinic of Child and Adolescents Psychiatry Goethe\u2010University of Frankfurt Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Capovilla","sequence":"additional","affiliation":[{"name":"Department of Child Neuropsychiatry Epilepsy Center C. 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