{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:58:38Z","timestamp":1791223118484,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T00:00:00Z","timestamp":1382918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wellcome Trust","award":["060214\/HC\/RL\/MW\/kj"],"award-info":[{"award-number":["060214\/HC\/RL\/MW\/kj"]}]},{"name":"Department of Health's National Institute for Health Research Biomedical Research Centres"},{"name":"GOSH Children's Charity"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Childhood convulsive status epilepticus (<jats:styled-content style=\"fixed-case\">CSE<\/jats:styled-content>), in particular prolonged febrile seizures (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>), has been linked with mesial temporal sclerosis (<jats:styled-content style=\"fixed-case\">MTS<\/jats:styled-content>). Previous studies have shown that hippocampal injury occurs in the acute phase immediately following <jats:styled-content style=\"fixed-case\">CSE<\/jats:styled-content>, but little is known about the longer term evolution of such injury. This study aimed to investigate the longer term outcome of childhood <jats:styled-content style=\"fixed-case\">CSE<\/jats:styled-content> with sequential magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) looking for progressive hippocampal injury during the first year post\u2010<jats:styled-content style=\"fixed-case\">CSE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty children (0.18\u201315.5\u00a0years) underwent brain <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> 1\u00a0month post\u2010<jats:styled-content style=\"fixed-case\">CSE<\/jats:styled-content>, 50 with a repeat <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> at 6\u00a0months and 46 with repeat <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> at 12\u00a0months post\u2010<jats:styled-content style=\"fixed-case\">CSE<\/jats:styled-content>. Thirty\u2010one control subjects without neurologic problems had a single brain <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> for comparison. Hippocampal volumes were measured from each <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> scan by two independent observers, and hippocampal growth rates were estimated in each patient with suitable imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Findings<\/jats:title><jats:p>Hippocampal volume loss was found in 20\u201330% of patients and was not associated with the etiology or clinical features of <jats:styled-content style=\"fixed-case\">CSE<\/jats:styled-content>, including seizure duration or focality. A borderline association was found between a history of previous seizures (p\u00a0=\u00a00.063) and the number of previous febrile seizures (p\u00a0=\u00a00.051), suggesting that multiple insults may be important in the pathogenesis of progressive hippocampal injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>It is apparent that progressive hippocampal damage can occur after <jats:styled-content style=\"fixed-case\">CSE<\/jats:styled-content> of any etiology and is not limited to <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>. Repeated seizures may play an important role, but further follow\u2010up is needed to determine any other risk factors and proportion of children showing initial volume loss progress to clinical <jats:styled-content style=\"fixed-case\">MTS<\/jats:styled-content> and temporal lobe epilepsy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.12426","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T14:26:47Z","timestamp":1382970407000},"page":"2108-2115","source":"Crossref","is-referenced-by-count":37,"title":["Hippocampal volume loss following childhood convulsive status epilepticus is not limited to prolonged febrile seizures"],"prefix":"10.1111","volume":"54","author":[{"given":"Michael","family":"Yoong","sequence":"first","affiliation":[{"name":"Neurosciences Unit UCL Institute of Child Health London United Kingdom"},{"name":"Imaging and Biophysics Unit UCL Institute of Child Health London United Kingdom"},{"name":"Young Epilepsy Lingfield Surrey United 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