{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T12:51:52Z","timestamp":1783774312616,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"s9","license":[{"start":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T00:00:00Z","timestamp":1386806400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2013,12]]},"abstract":"Summary<\/jats:title>The goal of the present study was to evaluate the clinical characteristics and postoperative seizure outcome of epileptogenic tumors associated with focal cortical dysplasias (FCD<\/jats:styled-content>s) compared to both solitaryFCD<\/jats:styled-content>type I and solitary tumors. Particular attention is given toFCD<\/jats:styled-content>typeIII<\/jats:styled-content>b (tumors associated withFCD<\/jats:styled-content>type I), which have been recently classified as a separate entity. We retrospectively reviewed the clinical charts of 1,109 patients who were operated on for drug\u2010resistant focal epilepsy, including 492 patients with a histologic diagnosis of solitaryFCD<\/jats:styled-content>I andII<\/jats:styled-content>(83 and 157 cases, respectively), solitary tumors (179 cases), andFCD<\/jats:styled-content>\u2010associated tumors (73 cases, 58 of which met the criteria ofFCD III<\/jats:styled-content>b of the new International League Against Epilepsy [ILAE<\/jats:styled-content>] classification). The different subgroups were evaluated for clinical characteristics and postoperative surgical outcome. Clinical variables and postoperative seizure outcome of patients with coexisting tumor andFCD<\/jats:styled-content>s (FCD III<\/jats:styled-content>b and tumor associatedFCD II<\/jats:styled-content>) were similar to those of patients with a solitary tumor and differed significantly from patients with solitaryFCD<\/jats:styled-content>s. Nevertheless, tumors associated withFCD<\/jats:styled-content>s are characterized by a striking male predominance and a higher seizure frequency as compared to solitary tumors. Patients with drug\u2010resistant focal epilepsy secondary to a solitary tumor or with a tumor\u2010associatedFCD<\/jats:styled-content>have similar basic clinical presentation and postoperative seizure outcome. Nevertheless, the epileptogenic contribution of the associatedFCD<\/jats:styled-content>s can be crucial, and it needs to be adequately assessed. The impact ofFCD<\/jats:styled-content>on tumor\u2010related epilepsy deserves future research in order to optimize the surgical strategies aimed at seizure relief.<\/jats:p>","DOI":"10.1111\/epi.12455","type":"journal-article","created":{"date-parts":[[2013,12,13]],"date-time":"2013-12-13T04:55:40Z","timestamp":1386910540000},"page":"115-122","source":"Crossref","is-referenced-by-count":56,"title":["Epilepsy surgery of focal cortical dysplasia\u2013associated tumors"],"prefix":"10.1111","volume":"54","author":[{"given":"Massimo","family":"Cossu","sequence":"first","affiliation":[{"name":"\u201cC. Munari\u201d Epilepsy Surgery Center Niguarda Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalila","family":"Fuschillo","sequence":"additional","affiliation":[{"name":"Service of Pathology Niguarda Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Bramerio","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery Department of Neurosciences and Sense Organs Milan University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Galli","sequence":"additional","affiliation":[{"name":"Service of Pathology Lodi Hospital Lodi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Gozzo","sequence":"additional","affiliation":[{"name":"\u201cC. Munari\u201d Epilepsy Surgery Center Niguarda Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Pelliccia","sequence":"additional","affiliation":[{"name":"\u201cC. Munari\u201d Epilepsy Surgery Center Niguarda Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Casaceli","sequence":"additional","affiliation":[{"name":"\u201cC. Munari\u201d Epilepsy Surgery Center Niguarda Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Tassi","sequence":"additional","affiliation":[{"name":"\u201cC. Munari\u201d Epilepsy Surgery Center Niguarda Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Lo Russo","sequence":"additional","affiliation":[{"name":"\u201cC. Munari\u201d Epilepsy Surgery Center Niguarda Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2011.07.004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000183747.05269.2d"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02777.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e31827d1161"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2009.0262"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000176656.33523.1e"},{"key":"e_1_2_6_8_1","first-page":"609","volume-title":"Surgical treatment of the epilepsies","author":"Engel J","year":"1993"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00619.x"},{"key":"e_1_2_6_10_1","volume-title":"World Health Organization classification of tumors. 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A ten\u2010year\u2010experience with a series of 327 consecutive resections","volume":"4","author":"Pasquier B","year":"2002","journal-title":"Epileptic Disord"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf175"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2010.0327"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2012.00582.x"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.12455","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.12455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T13:03:48Z","timestamp":1716296628000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.12455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":16,"journal-issue":{"issue":"s9","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/epi.12455"],"URL":"https:\/\/doi.org\/10.1111\/epi.12455","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}