{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:49:22Z","timestamp":1791208162074,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T00:00:00Z","timestamp":1386288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Epilepsy Foundation of America (ZH)"},{"name":"NIH-NINDS K23","award":["NS044936"],"award-info":[{"award-number":["NS044936"]}]},{"name":"The Leff Family Foundation (JMS)"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health (NIH","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Temporal lobe epilepsy (<jats:styled-content style=\"fixed-case\">TLE<\/jats:styled-content>) affects brain areas beyond the temporal lobes due to connections of the hippocampi and other temporal lobe structures. Using functional connectivity magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>), we determined the changes of hippocampal networks in <jats:styled-content style=\"fixed-case\">TLE<\/jats:styled-content> to assess for a more complete distribution of abnormality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Regions of interest (<jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content>s) were defined in the right and left hippocampi in three groups of participants: left <jats:styled-content style=\"fixed-case\">TLE<\/jats:styled-content> (n\u00a0=\u00a013), right <jats:styled-content style=\"fixed-case\">TLE<\/jats:styled-content> (n\u00a0=\u00a011), and healthy controls (n\u00a0=\u00a016). Brain regions functionally connected to these <jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content>s were identified by correlating resting\u2010state low\u2010frequency functional MRI (f<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) blood oxygenation level\u2013dependent (BOLD) signal fluctuations. The grouped results were compared using independent sample <jats:italic>t<\/jats:italic>\u2010test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TLE<\/jats:styled-content> was associated with increased hippocampal connectivity involving several key areas of the limbic network (temporal lobe, insula, thalamus), frontal lobes, angular gyrus, basal ganglia, brainstem, and cerebellum, along with reduced connectivity involving areas of the sensorimotor cortex (visual, somatosensory, auditory, primary motor) and the default mode network (precuneus). Left <jats:styled-content style=\"fixed-case\">TLE<\/jats:styled-content> had more marked connectivity changes than right <jats:styled-content style=\"fixed-case\">TLE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>The observed connectivity changes in <jats:styled-content style=\"fixed-case\">TLE<\/jats:styled-content> indicate dysfunctional networks that underlie widespread brain involvement in <jats:styled-content style=\"fixed-case\">TLE<\/jats:styled-content>. There are identifiable differences in the connectivity of the hippocampi between left and right <jats:styled-content style=\"fixed-case\">TLE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.12476","type":"journal-article","created":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T23:50:40Z","timestamp":1386373840000},"page":"137-145","source":"Crossref","is-referenced-by-count":213,"title":["Functional connectivity of hippocampal networks in temporal lobe epilepsy"],"prefix":"10.1111","volume":"55","author":[{"given":"Zulfi","family":"Haneef","sequence":"first","affiliation":[{"name":"Department of Neurology Baylor College of Medicine Houston Texas U.S.A"},{"name":"Department of Neurology Michael E DeBakey VA Medical Center Houston Texas U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agatha","family":"Lenartowicz","sequence":"additional","affiliation":[{"name":"Department of Psychology University of California Los Angeles California 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