{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:17:10Z","timestamp":1792081030687,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Research Foundation of Korea Grant funded by the Korean Government","award":["20100004827, 20110005418"],"award-info":[{"award-number":["20100004827, 20110005418"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Aberrant thalamocortical network has been hypothesized to play a crucial role in the fundamental pathogenesis underlying idiopathic generalized epilepsy (<jats:styled-content style=\"fixed-case\">IGE<\/jats:styled-content>). We aimed to investigate alterations of thalamocortical functional network in patients with IGE using thalamic seed\u2010based functional connectivity (<jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content>) analysis, and their relationships with frontal cognitive functions and clinical characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010nine <jats:styled-content style=\"fixed-case\">IGE<\/jats:styled-content> patients (31 with juvenile myoclonic epilepsy, 17 with <jats:styled-content style=\"fixed-case\">IGE<\/jats:styled-content> with generalized tonic\u2013clonic seizures only, one with juvenile absence epilepsy) and 42 control subjects were prospectively recruited. Voxel\u2010based morphometry (<jats:styled-content style=\"fixed-case\">VBM<\/jats:styled-content>) was first performed to detect thalamic region of gray matter (<jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>) reduction in patients compared to controls. Between\u2010group comparison of thalamocortical <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> was then carried out using resting\u2010state functional magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI)<\/jats:styled-content> analysis seeding at thalamic region of volume difference. In addition, thalamocortical <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> was correlated with frontal cognitive performance and clinical variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Neuropsychological assessment revealed that patients with IGE had poorer performance than controls on most of the frontal cognitive functions. <jats:styled-content style=\"fixed-case\">VBM<\/jats:styled-content> detected a reduction in <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> in the anteromedial thalamus in patients relative to controls. <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> analysis seeding at the anteromedial thalamus revealed a reduction of thalamocortical <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> in the bilateral medial prefrontal cortex and precuneus\/posterior cingulate cortex in patients with IGE compared to controls. Thalamocortical <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> strength of bilateral medial prefrontal cortex correlated negatively with disease duration, but did not correlate with seizure frequency or frontal cognitive functions in patients with IGE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Our results indicate that <jats:styled-content style=\"fixed-case\">IGE<\/jats:styled-content> is associated with decreased thalamocortical <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> between anteromedial thalamus and medial prefrontal cortex and precuneus\/posterior cingulate cortex. Our finding of greater reduction of medial prefrontal <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> in relation to increasing disease duration suggests that thalamoprefrontal network abnormality, the proposed pathophysiologic mechanism underlying <jats:styled-content style=\"fixed-case\">IGE<\/jats:styled-content>, may be the consequence of the long\u2010standing burden of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.12580","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T19:08:33Z","timestamp":1395342513000},"page":"592-600","source":"Crossref","is-referenced-by-count":107,"title":["Altered thalamocortical functional connectivity in idiopathic generalized epilepsy"],"prefix":"10.1111","volume":"55","author":[{"given":"Jung Bin","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology Korea University Guro Hospital Korea University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010il","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Radiology Korea University Guro Hospital Korea University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo\u2010Keun","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Neurology Korea University Guro Hospital Korea University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungmi","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Neurology Korea University Guro Hospital Korea University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong\u2010Beom","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Neurology Korea University Guro Hospital Korea University College of Medicine Seoul 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