{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:32:43Z","timestamp":1778617963679,"version":"3.51.4"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T00:00:00Z","timestamp":1395878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The co\u2010occurrence of absence and mesial temporal lobe epilepsy is rare in both humans and animal models. Consistent with this, rat models of absence epilepsy, including genetic absence epilepsy rats from Strasbourg (<jats:styled-content style=\"fixed-case\">GAERS<\/jats:styled-content>), are resistant to experimental temporal lobe epileptogenesis, in particular by amygdala kindling. Structures within the cortical\u2010thalamocortical system are critically involved in the generation and maintenance of the electrographic spike\u2010and\u2010wave discharges (SWDs) that characterize absence seizures. Using in vivo electrophysiologic recordings, this study investigated the role of thalamocortical circuitry in the generalization of amygdala\u2010kindling induced seizures in the <jats:styled-content style=\"fixed-case\">GAERS<\/jats:styled-content> and the nonepileptic control (<jats:styled-content style=\"fixed-case\">NEC<\/jats:styled-content>) strain of Wistar rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">GAERS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NEC<\/jats:styled-content> rats were implanted with a stimulating electrode in amygdala and stimulated at afterdischarge threshold twice daily to a maximum number of 30 stimulations. Thereafter extracellular single neuron recordings were performed in vivo under neuroleptanesthesia in the thalamocortical network.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In <jats:styled-content style=\"fixed-case\">NEC<\/jats:styled-content> rats, amygdala kindling induced convulsive class V seizures and altered characteristics of neuronal activity in the thalamic reticular nucleus (<jats:styled-content style=\"fixed-case\">TRN<\/jats:styled-content>), in particular decreased firing rates and increased burst firing patterns. Less marked changes were seen in other regions examined: the ventroposteromedial nucleus of thalamus (<jats:styled-content style=\"fixed-case\">VPM<\/jats:styled-content>), the <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>3 region of the hippocampus, and the deep layers (V\/<jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content>) of the cortex. <jats:styled-content style=\"fixed-case\">GAERS<\/jats:styled-content> did not progress beyond class <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> seizures, with a matched number of kindling stimulations, and the thalamic neuronal firing alterations observed in <jats:styled-content style=\"fixed-case\">NEC<\/jats:styled-content> rats were not seen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>These data suggest that the <jats:styled-content style=\"fixed-case\">TRN<\/jats:styled-content> plays an important role in kindling resistance in <jats:styled-content style=\"fixed-case\">GAERS<\/jats:styled-content> and is central to the control of secondary generalization of limbic seizures.<\/jats:p><jats:p>A PowerPoint slide summarizing this article is available for download in the Supporting Information section <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.12592\/supinfo\">here<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.12592","type":"journal-article","created":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T21:27:09Z","timestamp":1395955629000},"page":"654-665","source":"Crossref","is-referenced-by-count":11,"title":["The effect of amygdala kindling on neuronal firing patterns in the lateral thalamus in the <scp>GAERS<\/scp> model of absence epilepsy"],"prefix":"10.1111","volume":"55","author":[{"given":"Nihan","family":"\u00c7ar\u00e7ak","sequence":"first","affiliation":[{"name":"Department of Pharmacology Faculty of Pharmacy Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Medicine Royal Melbourne Hospital University of Melbourne Melbourne Vic. 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