{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:37:37Z","timestamp":1769164657392,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,11]],"date-time":"2014-04-11T00:00:00Z","timestamp":1397174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Studies of focal epilepsy have revealed abnormalities of language organization; however, little attention has been paid to disorders of reading in this group. We hypothesized that language functional magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">fMRI)<\/jats:styled-content> would reveal differences in language organization between focal epilepsy patients with and without reading difficulties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted language <jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content> studies of 10 focal epilepsy patients with reading difficulties, 34 focal epilepsy patients without reading difficulties, and 42 healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We defined regions of interests on the basis of activation patterns on an orthographic lexical retrieval task. Comparison of activations within these <jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content>s on a second Noun\u2010Verb task revealed epilepsy\u2010related effects (relative to healthy controls: reduced activation in left inferior frontal cortex), as well as greater activation in the right temporooccipital cortex specific to the reading difficulty group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>These findings identify a focal epilepsy effect in the left frontal region (present in patients with and without reading difficulties), and a functional abnormality specific to the reading difficulty group localized to right temporooccipital cortex\u2014a region implicated in lexicosemantic processing. Our observations suggest a failure of left hemisphere specialization among focal epilepsy patients with reading difficulties.<\/jats:p><jats:p>A PowerPoint slide summarizing this article is available for download in the Supporting Information section <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.12607\/supinfo\">here<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.12607","type":"journal-article","created":{"date-parts":[[2014,4,11]],"date-time":"2014-04-11T23:32:58Z","timestamp":1397259178000},"page":"746-753","source":"Crossref","is-referenced-by-count":16,"title":["Reading difficulty is associated with failure to lateralize temporooccipital function"],"prefix":"10.1111","volume":"55","author":[{"given":"Chris","family":"Tailby","sequence":"first","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health Melbourne Victoria Australia"},{"name":"School of Psychological Sciences University of Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Weintrob","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology Austin Health Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael M.","family":"Saling","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences University of Melbourne Victoria Australia"},{"name":"Department of Neuropsychology Austin Health Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carly","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme D.","family":"Jackson","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health 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