{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:11:32Z","timestamp":1790359892780,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T00:00:00Z","timestamp":1400716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Summary<\/jats:title>Charlotte, a little girl with SCN<\/jats:styled-content>1A<\/jats:styled-content><\/jats:italic>\u2010confirmed D<\/jats:styled-content>ravet syndrome, was recently featured in a special that aired on CNN<\/jats:styled-content>. Through exhaustive personal research and assistance from a C<\/jats:styled-content>olorado\u2010based medical marijuana group (R<\/jats:styled-content>ealm of C<\/jats:styled-content>aring), C<\/jats:styled-content>harlotte's mother started adjunctive therapy with a high concentration cannabidiol\/\u03949<\/jats:sup>\u2010tetrahydrocannabinol (CBD<\/jats:styled-content>:THC)<\/jats:styled-content> strain of cannabis, now known as C<\/jats:styled-content>harlotte's W<\/jats:styled-content>eb. This extract, slowly titrated over weeks and given in conjunction with her existing antiepileptic drug regimen, reduced C<\/jats:styled-content>harlotte's seizure frequency from nearly 50 convulsive seizures per day to now 2\u20133 nocturnal convulsions per month. This effect has persisted for the last 20\u00a0months, and Charlotte has been successfully weaned from her other antiepileptic drugs. We briefly review some of the history, preclinical and clinical data, and controversies surrounding the use of medical marijuana for the treatment of epilepsy, and make a case that the desire to isolate and treat with pharmaceutical grade compounds from cannabis (specifically CBD<\/jats:styled-content>) may be inferior to therapy with whole plant extracts. Much more needs to be learned about the mechanisms of antiepileptic activity of the phytocannabinoids and other constituents of C<\/jats:styled-content>annabis sativa<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/epi.12610","type":"journal-article","created":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T14:10:08Z","timestamp":1400767808000},"page":"783-786","source":"Crossref","is-referenced-by-count":208,"title":["The case for medical marijuana in epilepsy"],"prefix":"10.1111","volume":"55","author":[{"given":"Edward","family":"Maa","sequence":"first","affiliation":[{"name":"Comprehensive Epilepsy Program Denver Health and Hospitals Denver Colorado U.S.A"},{"name":"Department of Neurology University of Colorado Denver Colorado U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige","family":"Figi","sequence":"additional","affiliation":[{"name":"Dravet syndrome parent Colorado Springs Colorado U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,22]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"1","volume-title":"Cannabinoids as therapeutic agents","author":"Mechoulam R","year":"1986"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1975.03260160054015"},{"key":"e_1_2_5_4_1","first-page":"439","article-title":"Complex partial seizure symptoms affected by marijuana abuse","volume":"51","author":"Ellison JM","year":"1990","journal-title":"J Clin Psychol"},{"key":"e_1_2_5_5_1","first-page":"474","article-title":"Grand mal convulsions subsequent to marijuana use. Case report","volume":"28","author":"Keeler MH","year":"1967","journal-title":"Dis Nerv Syst"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1973.tb10660.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1975.tb06080.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1975.tb06071.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000137430"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.09.011"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2004.07.007"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-005-6978-1"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707460"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01238.x"},{"key":"e_1_2_5_15_1","unstructured":"MaaEH.Use of Complementary and Alternative Medicine in an Urban County Hospital Epilepsy Clinic. Platform presentation. European Neurological Society Annual Meeting2012."}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.12610","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.12610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:25:15Z","timestamp":1696357515000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.12610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,22]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/epi.12610"],"URL":"https:\/\/doi.org\/10.1111\/epi.12610","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,22]]}}}