{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:20:42Z","timestamp":1757542842130},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,4,11]],"date-time":"2014-04-11T00:00:00Z","timestamp":1397174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We investigated the cognitive profile of structural occipital lobe epilepsy (<jats:styled-content style=\"fixed-case\">OLE<\/jats:styled-content>) and whether verbal memory impairment is selectively associated with left temporal lobe hypometabolism on [18F]\u2010fluorodeoxyglucose positron emission tomography (<jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>). Nine patients with OLE, ages 8\u201329 years, completed presurgical neuropsychological assessment. Composite measures were calculated for intelligence quotient (<jats:styled-content style=\"fixed-case\">IQ)<\/jats:styled-content>, speed, attention, verbal memory, nonverbal memory, and executive functioning. In addition, the Wisconsin Card Sorting Test (<jats:styled-content style=\"fixed-case\">WCST<\/jats:styled-content>) was used as a specific measure of frontal lobe functioning. Presurgical <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> was analyzed with statistical parametric mapping in 8 patients relative to 16 healthy volunteers. Mild impairments were evident for <jats:styled-content style=\"fixed-case\">IQ<\/jats:styled-content>, speed, attention, and executive functioning. Four patients demonstrated moderate or severe verbal memory impairment. Temporal lobe hypometabolism was found in seven of eight patients. Poorer verbal memory was associated with left temporal lobe hypometabolism (p\u00a0=\u00a00.002), which was stronger (p\u00a0=\u00a00.03 and p\u00a0=\u00a00.005, respectively) than the association of left temporal lobe hypometabolism with executive functioning or with performance on the <jats:styled-content style=\"fixed-case\">WCST<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">OLE<\/jats:styled-content> is associated with widespread cognitive comorbidity, suggesting cortical dysfunction beyond the occipital lobe. Verbal memory impairment is selectively associated with left temporal lobe hypometabolism in <jats:styled-content style=\"fixed-case\">OLE<\/jats:styled-content>, supporting a link between neuropsychological dysfunction and remote hypometabolism in focal epilepsy.<\/jats:p><jats:p>A PowerPoint slide summarizing this article is available for download in the Supporting Information section <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.12623\/supinfo\">here<\/jats:ext-link>.<\/jats:p>","DOI":"10.1111\/epi.12623","type":"journal-article","created":{"date-parts":[[2014,4,11]],"date-time":"2014-04-11T23:33:19Z","timestamp":1397259199000},"source":"Crossref","is-referenced-by-count":16,"title":["The cognitive profile of occipital lobe epilepsy and the selective association of left temporal lobe hypometabolism with verbal memory impairment"],"prefix":"10.1111","volume":"55","author":[{"given":"Alex A.","family":"Knopman","sequence":"first","affiliation":[{"name":"Department of Psychology Macquarie University Sydney New South Wales Australia"},{"name":"Department of Medical Psychology Westmead Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong H.","family":"Wong","sequence":"additional","affiliation":[{"name":"Sydney Medical School University of Sydney Sydney New South Wales Australia"},{"name":"Department of Neurology Westmead Hospital and The Children's Hospital at Westmead Wentworthville New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Department of Psychology Macquarie University Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judi","family":"Homewood","sequence":"additional","affiliation":[{"name":"Department of Psychology Macquarie University Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Sydney Medical School University of Sydney Sydney New South Wales Australia"},{"name":"Department of Molecular Imaging Royal Prince Alfred Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest","family":"Somerville","sequence":"additional","affiliation":[{"name":"Institute of Neurological Sciences Prince of Wales Hospital Sydney New South Wales Australia"},{"name":"Faculty of Medicine University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Eberl","sequence":"additional","affiliation":[{"name":"Sydney Medical School University of Sydney Sydney New South Wales Australia"},{"name":"Department of Molecular Imaging Royal Prince Alfred Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingfeng","family":"Wen","sequence":"additional","affiliation":[{"name":"Sydney Medical School University of Sydney Sydney New South Wales Australia"},{"name":"Department of Molecular Imaging Royal Prince Alfred Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Fulham","sequence":"additional","affiliation":[{"name":"Sydney Medical School University of Sydney Sydney New South Wales Australia"},{"name":"Department of Molecular Imaging Royal Prince Alfred Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew F.","family":"Bleasel","sequence":"additional","affiliation":[{"name":"Sydney Medical School University of Sydney Sydney New South Wales Australia"},{"name":"Department of Neurology Westmead Hospital and The Children's Hospital at Westmead Wentworthville New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/115.6.1655"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6650-z"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2009.02.040"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440112"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2011.11.014"},{"key":"e_1_2_7_7_1","first-page":"609","volume-title":"Surgical treatment of the epilepsies","author":"Engel J","year":"1993"},{"key":"e_1_2_7_8_1","volume-title":"Wisconsin Card Sorting Test (WCST) manual, revised and expanded","author":"Heaton R","year":"1993"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02552.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1959.tb00346.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-006-9002-x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10133"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617707070828"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.12.2283"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000242628.26978.e2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn218"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.12623","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.12623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:34:32Z","timestamp":1695490472000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.12623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,11]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/epi.12623"],"URL":"https:\/\/doi.org\/10.1111\/epi.12623","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,11]]}}}