{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T10:46:10Z","timestamp":1776854770213,"version":"3.51.2"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T00:00:00Z","timestamp":1399593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Summary<\/jats:title>Seizures are observed with a frequency of 3\u201321% in children with fetal alcohol spectrum disorders (FASD<\/jats:styled-content>). However, clinical, neuroradiologic, and electroencephalography (EEG<\/jats:styled-content>) features are poorly described. In this study, 13 patients with FASD<\/jats:styled-content> and epilepsy or seizures were identified retrospectively from the databases of seven Italian pediatric neurology divisions. Eleven children were affected by epilepsy, and two had at least one documented seizure. Both generalized and focal seizures were observed. EEG<\/jats:styled-content> showed diffuse or focal epileptic activity; two children developed electric status epilepticus during sleep (ESES<\/jats:styled-content>). Structural brain anomalies, including polymicrogyria, nodular heterotopia, atrophy, and Arnold\u2010Chiari type 1 malformation, were discovered in almost 50% of patients. Control of seizures was not difficult to obtain in 11 cases; one patient showed pharmacoresistant epilepsy. EEG<\/jats:styled-content> and clinical follow\u2010up are recommended in children with FASD<\/jats:styled-content> and epilepsy, since severe conditions requiring aggressive treatment, such as in ESES<\/jats:styled-content>, may develop. Neuroradiological evaluation is warranted because several types of brain anomalies could be associated with maternal alcohol consumption during pregnancy.<\/jats:p>A PowerPoint slide summarizing this article is available for download in the Supporting Information section here<\/jats:ext-link>.<\/jats:p>","DOI":"10.1111\/epi.12638","type":"journal-article","created":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T20:24:42Z","timestamp":1399667082000},"source":"Crossref","is-referenced-by-count":34,"title":["Seizures in fetal alcohol spectrum disorders: Evaluation of clinical, electroencephalographic, and neuroradiologic features in a pediatric case series"],"prefix":"10.1111","volume":"55","author":[{"given":"Francesco","family":"Nicita","sequence":"first","affiliation":[{"name":"Child Neurology Division Department of Pediatrics Sapienza University of Roma Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Verrotti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Perugia Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Pruna","sequence":"additional","affiliation":[{"name":"Division of Child Neurology and Psychiatry Azienda University Hospital of Cagliari Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Striano","sequence":"additional","affiliation":[{"name":"Pediatric Neurology and Muscular Diseases Unit Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health University of Genoa \u2018G. Gaslini\u2019 Institute Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Capovilla","sequence":"additional","affiliation":[{"name":"Epilepsy Center Department of Child Neuropsychiatry C Poma Hospital Mantova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Savasta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Valentina","family":"Spart\u00e0","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Parisi","sequence":"additional","affiliation":[{"name":"NESMOS Department Child Neurology Headache Pediatric Center Pediatric Sleep Disorders Sapienza University of Roma Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Parlapiano","sequence":"additional","affiliation":[{"name":"Unit of Genetic Department of Pediatrics Sapienza University of Roma Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Tarani","sequence":"additional","affiliation":[{"name":"Unit of Genetic Department of Pediatrics Sapienza University of Roma Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Spalice","sequence":"additional","affiliation":[{"name":"Child Neurology Division Department of Pediatrics Sapienza University of Roma Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0259"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073811428377"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01184.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02522.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.68"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph8062331"},{"key":"e_1_2_8_8_1","first-page":"476","article-title":"Les enfants de parentes alcoholiques anomalies observees a propos de 127 cas","volume":"25","author":"Lemoin P","year":"1968","journal-title":"Quest Med"},{"key":"e_1_2_8_9_1","first-page":"1051","article-title":"Fetal Alcohol syndrome and seizure disorder","volume":"43","author":"O'Malley K","year":"1998","journal-title":"Can J Psychol"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1052428"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02274.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20629"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2006.09.006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182343343"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.12638","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.12638","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:26:39Z","timestamp":1696357599000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.12638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,9]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/epi.12638"],"URL":"https:\/\/doi.org\/10.1111\/epi.12638","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,9]]}}}