{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:18:09Z","timestamp":1761513489818},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,7,9]],"date-time":"2014-07-09T00:00:00Z","timestamp":1404864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We observed a substantial increase in age\u2010adjusted hospitalization rates in the United States National Hospital Discharge Survey data from 1996 to 2010. We aimed to assess reasons for this increase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The National Hospital Discharge Survey collected data on a national sample of short\u2010term hospital stays in nonfederal hospitals. We determined epilepsy\u2010related discharge diagnoses by age, gender, and region using weighted analysis, and estimated age\u2010adjusted rates and annual percent changes using regression analysis. We also looked at epilepsy as the principal discharge diagnosis in the Nationwide Inpatient Sample of the Healthcare Cost and Utilization Project.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the <jats:styled-content style=\"fixed-case\">United States<\/jats:styled-content>, on average, nearly 110,000 more admissions were reported each year with epilepsy as the principal discharge diagnosis in 2006\u20132010 than in 1996\u20132005, a 2.7\u2010fold increase in hospitalization rates from epilepsy. During this period, there were more hospitalizations with principal discharge diagnosis of epilepsy not otherwise specified, and among older patients. The number of discharges with seizure not otherwise specified dropped dramatically after 2006, and was more evident among pediatric patients. The age\u2010adjusted rates of hospital stays combining discharges with any mention of epilepsy (345.<jats:styled-content style=\"fixed-case\">XX<\/jats:styled-content>) or seizures unspecified (780.39) in seven discharge diagnoses, were similar in 1996\u20132005 and 2006\u20132010.\n<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>We postulate that the excess in hospitalizations with epilepsy as first discharge diagnosis in 2006\u20132010 in the <jats:styled-content style=\"fixed-case\">United States<\/jats:styled-content> was related to the changes in coding in 2006. Any use of <jats:styled-content style=\"fixed-case\">U.S.<\/jats:styled-content> hospital discharge data with epilepsy\u2010related diagnosis after that date will require further validation.<\/jats:p><jats:p>A PowerPoint slide summarizing this article is available for download in the Supporting Information section <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.12719\/suppinfo\">here<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.12719","type":"journal-article","created":{"date-parts":[[2014,7,9]],"date-time":"2014-07-09T19:35:54Z","timestamp":1404934554000},"page":"1347-1354","source":"Crossref","is-referenced-by-count":11,"title":["Why U.S. epilepsy hospital stays rose in 2006"],"prefix":"10.1111","volume":"55","author":[{"given":"V\u00edctor M.","family":"C\u00e1rdenas","sequence":"first","affiliation":[{"name":"Department of Epidemiology College of Public Health University of Arkansas for Medical Sciences Little Rock Arkansas U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo C.","family":"Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Neurology Weill Cornell Medical College Methodist Neurological Institute Houston Texas U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, and Michael &amp; Susan Dell Center for Healthy Living University of Texas School of Public Health Austin Texas U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Allen","family":"Hauser","sequence":"additional","affiliation":[{"name":"Departments Neurology and Epidemiology Gertrude H. Sergievsky Center Columbia University New York New York U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.9.1407"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2307\/3342463"},{"key":"e_1_2_8_4_1","volume-title":"Epidemiology","author":"Gordis L","year":"2014"},{"key":"e_1_2_8_5_1","unstructured":"HolmquistL RussoCA ElixhauserA.Hospitalizations for Epilepsy and Convulsions 2005. HCUP Statistical Brief #46. January 2008.Agency for Healthcare Research and Quality Rockville MD. Available at:http:\/\/www.hcup-us.ahrq.gov\/reports\/statbriefs\/sb46.pdf. 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Change Request 5142: 38.http:\/\/www.cms.gov\/Regulations-and-Guidance\/Guidance\/Transmittals\/Downloads\/R990CP.pdf. Accessed March 12 2014."},{"key":"e_1_2_8_12_1","first-page":"322","volume-title":"Learning to code with ICD\u20109\u2010CM for health information management and health services administration","author":"Falen TJ","year":"2007"},{"key":"e_1_2_8_13_1","unstructured":"HCUPnet.Healthcare Cost and Utilization Project (HCUP). 1996\u20102011. Agency for Healthcare Research and Quality Rockville MD.http:\/\/hcupnet.ahrq.gov\/. 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