{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:48:05Z","timestamp":1791330485082,"version":"4.3.1"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,7,24]],"date-time":"2014-07-24T00:00:00Z","timestamp":1406160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The Genetic Absence Epilepsy Rats from Strasbourg (<jats:styled-content style=\"fixed-case\">GAERS)<\/jats:styled-content> is a genetic model, derived from Wistar rats by selective breeding. In all previous studies, <jats:styled-content style=\"fixed-case\">GAERS<\/jats:styled-content> were compared to their paired selected strain not expressing spike\u2010and\u2010wave discharges (<jats:styled-content style=\"fixed-case\">SWD<\/jats:styled-content>s), namely nonepileptic controls (<jats:styled-content style=\"fixed-case\">NEC<\/jats:styled-content>s). Because the occurrence\/absence of <jats:styled-content style=\"fixed-case\">SWD<\/jats:styled-content>s is of polygenic origin, some other traits could have been selected along with occurrence\/absence of <jats:styled-content style=\"fixed-case\">SWD<\/jats:styled-content>s. Therefore, we explored the importance of using a second control group consisting in Wistar rats, the strain of origin of <jats:styled-content style=\"fixed-case\">GAERS<\/jats:styled-content>, in addition to <jats:styled-content style=\"fixed-case\">NEC<\/jats:styled-content>s, on locomotion and anxiety in <jats:styled-content style=\"fixed-case\">GAERS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A test battery encompassing home\u2010cage, open\u2010field, beam\u2010walking and elevated plus\u2010maze evaluations was used. In addition, stereologic analyses were performed to assess the volume of thalamus, amygdala, and hippocampus. The occurrence\/absence of <jats:styled-content style=\"fixed-case\">SWD<\/jats:styled-content>s was determined in all three strains by electroencephalography (<jats:styled-content style=\"fixed-case\">EEG)<\/jats:styled-content> recording.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When compared to <jats:styled-content style=\"fixed-case\">NEC<\/jats:styled-content>s and Wistars, <jats:styled-content style=\"fixed-case\">GAERS<\/jats:styled-content> displayed lower exploratory activity and fastened habituation to novelty. In the plus\u2010maze, scores of <jats:styled-content style=\"fixed-case\">GAERS<\/jats:styled-content> and Wistars were similar, but <jats:styled-content style=\"fixed-case\">NEC<\/jats:styled-content>s appeared significantly less anxious (possibly in association with increased amygdala volume); evidence for weaker anxiety in <jats:styled-content style=\"fixed-case\">NEC<\/jats:styled-content>s was also found in the open\u2010field evaluation. The volumetric study revealed increased thalamic volume in <jats:styled-content style=\"fixed-case\">GAERS<\/jats:styled-content> compared to both control groups. SWDs were present in all <jats:styled-content style=\"fixed-case\">GAERS<\/jats:styled-content> and in 80% of Wistars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Compared to the original Wistar strain as an additional control group, the selective breeding that generated the GAERS has no incidence on anxiety\u2010related behavior, conversely to the selection of SWD suppression in NECs, in which anxiety is attenuated. These findings point to the importance of using a second control group composed of Wistar rats in studies characterizing the behavioral profile of <jats:styled-content style=\"fixed-case\">GAERS<\/jats:styled-content>. Thereby, possible confusions between occurrence\/absence of <jats:styled-content style=\"fixed-case\">SWD<\/jats:styled-content>s and other features that come along with selection and\/or differential brain development induced by the genetic mutations are reduced.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.12738","type":"journal-article","created":{"date-parts":[[2014,7,24]],"date-time":"2014-07-24T21:53:11Z","timestamp":1406238791000},"page":"1460-1468","source":"Crossref","is-referenced-by-count":44,"title":["Anxiety and locomotion in Genetic Absence Epilepsy Rats from Strasbourg (<scp>GAERS<\/scp>): Inclusion of Wistar rats as a second control"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1131-178X","authenticated-orcid":false,"given":"Jos\u00e9 Eduardo","family":"Marques\u2010Carneiro","sequence":"first","affiliation":[{"name":"Laboratory of Cognitive and Adaptive Neuroscience (LNCA) Faculty of Psychology UMR 7364 University of Strasbourg 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