{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:27:52Z","timestamp":1790810872773,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Funded in part by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, the Office of Rare Diseases Research, National Center for Advancing Translational Sciences, and Fogarty International Center Training Grant D43 TW00114, all from the National Institutes of"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To develop a better understanding of mechanisms of seizures and long\u2010term epileptogenesis using neurocysticercosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A workshop was held bringing together experts in epilepsy and epileptogenesis and neurocysticercosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Human neurocysticercosis and parallel animal models offer a unique opportunity to understand basic mechanisms of seizures. Inflammatory responses to degenerating forms and later\u2010stage calcified parasite granulomas are associated with seizures and epilepsy. Other mechanisms may also be involved in epileptogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Naturally occurring brain infections with neurocysticercosis offer a unique opportunity to develop treatments for one of the world's most common causes of epilepsy and for the development of more general antiepileptogenic treatments. Key advantages stem from the time course in which an acute seizure heralds a start of the epileptogenic process, and radiographic changes of calcification and perilesional edema provide biomarkers of a chronic epileptic state.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.12849","type":"journal-article","created":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T06:26:42Z","timestamp":1419316002000},"page":"177-183","source":"Crossref","is-referenced-by-count":70,"title":["Neurocysticercosis: A natural human model of epileptogenesis"],"prefix":"10.1111","volume":"56","author":[{"given":"Theodore E.","family":"Nash","sequence":"first","affiliation":[{"name":"Laboratory of Parasitic Disease National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda Maryland U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhartha","family":"Mahanty","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Disease National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda Maryland U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Loeb","sequence":"additional","affiliation":[{"name":"Department of Neurology and Rehabilitation University of Illinois at Chicago Chicago Illinois U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Theodore","sequence":"additional","affiliation":[{"name":"Epilepsy Section National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda Maryland U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Friedman","sequence":"additional","affiliation":[{"name":"The Zlotowski Center for Neuroscience Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"},{"name":"Department of Medical Neuroscience Dalhousie University Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6041-9661","authenticated-orcid":false,"given":"Josemir W.","family":"Sander","sequence":"additional","affiliation":[{"name":"NIHR UCL Hospitals Biomedical Research Centre Department of Clinical &amp; Experimental Epilepsy UCL Institute of Neurology Queen Square London &amp; Epilepsy Society Buckinghamshire United Kingdom"},{"name":"Epilepsy Institute of the Netherlands Foundation Heemstede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gagandeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Neurology Dayan and Medical College Ludhiana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esper","family":"Cavalheiro","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery Federal University of Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar H.","family":"Del Brutto","sequence":"additional","affiliation":[{"name":"School of Medicine University Espiritu Santo Guayaquil Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo M.","family":"Takayanagui","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Behavior Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Fleury","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Research National Autonomous University of Mexico and National Institute of Neurology and Neurosurgery (INNN) Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Verastegui","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Sciences Faculty of Science and Philosophy University Peruana Cayetano Heredia Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Marie","family":"Preux","sequence":"additional","affiliation":[{"name":"UMR1094 INSERM CHU Limoges Institute of Neuroepidemiology and Tropical Neurology University of Limoges Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Montano","sequence":"additional","affiliation":[{"name":"US Naval Medical Research Unit 6 Callao Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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