{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:17:31Z","timestamp":1759033051430},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T00:00:00Z","timestamp":1415232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ERANET NEURON","award":["2009 2ap imaging"],"award-info":[{"award-number":["2009 2ap imaging"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Nonconvulsive status epilepticus (nc<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>) is a severe condition that may result in neurologic sequelae and epilepsy resistant to pharmacologic treatment. We analyze here seizure and electroencephalography (<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>) patterns and their correlation to the development of a chronic epileptic condition in a guinea pig model of focal nc<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>induced by intrahippocampal injection of kainic acid (<jats:styled-content style=\"fixed-case\">KA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Electrobehavioral patterns during nc<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>induced by unilateral injection of 1\u00a0\u03bcg of<jats:styled-content style=\"fixed-case\">KA<\/jats:styled-content>in the<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>1 region of the hippocampus were characterized by continuous video\u2010<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>monitoring in 13 guinea pigs bilaterally implanted with recording electrodes in the hippocampus and neocortex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Video\u2010<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>analysis demonstrates a high variability of seizure type and duration during<jats:styled-content style=\"fixed-case\">KA<\/jats:styled-content>\u2010induced nc<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>. Seizures showed focal signs correlated with diverse epileptiform<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>discharge distributions, either diffuse or localized. Nonfocal (bilateral motor) signs during seizures most likely correlated with a diffuse<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>pattern. The evolution into a chronic epileptic condition correlated neither with the severity of seizure pattern nor with the diffusion of the<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>discharges observed during the nc<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Video\u2010<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>monitoring in a guinea pig model of nc<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>induced by unilateral hippocampal injection of<jats:styled-content style=\"fixed-case\">KA<\/jats:styled-content>demonstrates a high variability of electrobehavioral patterns. We demonstrate that the seizure severity score during focal nc<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>is not a predictor of the evolution into a chronic epileptic condition of mesial temporal lobe epilepsy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.12850","type":"journal-article","created":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T18:44:39Z","timestamp":1415299479000},"page":"1978-1985","source":"Crossref","is-referenced-by-count":9,"title":["Variable electrobehavioral patterns during focal nonconvulsive status epilepticus induced by unilateral intrahippocampal injection of kainic acid"],"prefix":"10.1111","volume":"55","author":[{"given":"Salvatore","family":"Arcieri","sequence":"first","affiliation":[{"name":"Unit of Epileptology and Experimental Neurophysiology Fondazione Neurological Institute Carlo Besta Milan Italy"},{"name":"Unit of Clinical Neurophysiology Scientific Institute IRCCS E. Medea Bosisio Parini (LC) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Velotti","sequence":"additional","affiliation":[{"name":"Unit of Epileptology and Experimental Neurophysiology Fondazione Neurological Institute Carlo Besta Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"No\u00e8","sequence":"additional","affiliation":[{"name":"Unit of Epileptology and Experimental Neurophysiology Fondazione Neurological Institute Carlo Besta Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Carriero","sequence":"additional","affiliation":[{"name":"Unit of Epileptology and Experimental Neurophysiology Fondazione Neurological Institute Carlo Besta Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Cattalini","sequence":"additional","affiliation":[{"name":"Unit of Epileptology and Experimental Neurophysiology Fondazione Neurological Institute Carlo Besta Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Galbardi","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit of Scientific Direction Neurological Institute Carlo Besta Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vadym","family":"Gnatkovsky","sequence":"additional","affiliation":[{"name":"Unit of Epileptology and Experimental Neurophysiology Fondazione Neurological Institute Carlo Besta Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"de Curtis","sequence":"additional","affiliation":[{"name":"Unit of Epileptology and Experimental Neurophysiology Fondazione Neurological Institute Carlo Besta Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70074-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1684\/j.1950-6945.2005.tb00130.x","article-title":"Nonconvulsive status epilepticus: epilepsy research foundation workshop reports","volume":"7","author":"Walker M","year":"2005","journal-title":"Epileptic Disord"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2008.06.013"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.nrl.0000162954.76053.d2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199907000-00004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00401-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1999.tb00849.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00064-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03669.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2012.09.015"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2004.03.009"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(69)90128-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(72)90177-0"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)90177-X"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.10.011"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2008.01108.x"},{"key":"e_1_2_7_18_1","volume-title":"Stereotaxic atlas of the forebrain of the guinea pig","author":"Luparello TJ","year":"1967"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.04.019"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05320.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1996.0135"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182759766"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24081"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.12850","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.12850","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T20:45:40Z","timestamp":1717533940000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.12850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,6]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/epi.12850"],"URL":"https:\/\/doi.org\/10.1111\/epi.12850","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,6]]}}}