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The database was linked to the Medical Birth Registry of Norway. Depression and anxiety were assessed with validated questionnaires five times from the second trimester to 36\u00a0months after delivery. Blood was drawn for analysis of antiepileptic drug (<jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>) concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women with epilepsy more often had peripartum depression (26.7%) or anxiety (22.4%) than women without epilepsy (18.9% and 14.8%, respectively, p\u00a0&lt;\u00a00.001 for both comparisons) and women with other chronic diseases (23.1% and 18.4%, respectively, p\u00a0=\u00a00.03 and 0.01). Women using <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s during pregnancy were especially at risk regardless of <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> type. The risk further increased with the use of multiple <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s and with high doses and\/or plasma levels. Risk factors associated with peripartum depression and\/or anxiety in the epilepsy cohort were high seizure frequency, a history of physical and\/or sexual abuse, adverse socioeconomic factors, previous loss of a child, <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> use, unplanned pregnancy, and prepregnancy depression and\/or anxiety. The recovery rate 3\u00a0years after delivery was lower for women with epilepsy with a history of depression\/anxiety or physical\/sexual abuse than for women without epilepsy. Depressed women with epilepsy were less frequently treated with antidepressive drugs during pregnancy than women without epilepsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Women with epilepsy frequently have depression and anxiety during and after pregnancy. Patients at risk should be identified before delivery as depressive symptoms could be undertreated in this group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.12884","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T10:56:26Z","timestamp":1418986586000},"page":"28-39","source":"Crossref","is-referenced-by-count":81,"title":["Depression and anxiety in women with epilepsy during pregnancy and after delivery: A prospective population\u2010based cohort study on frequency, risk factors, medication, and prognosis"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5745-1094","authenticated-orcid":false,"given":"Marte Helene","family":"Bj\u00f8rk","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine University of Bergen Bergen Norway"},{"name":"Department of Neurology Haukeland University Hospital Bergen 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