{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:38:19Z","timestamp":1793392699238,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T00:00:00Z","timestamp":1421280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Leslie Munzer Neurological Institute","id":[{"id":"https:\/\/ror.org\/05ty23t08","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Summary<\/jats:title>\n \n Objective<\/jats:title>\n \n To assess symptoms of attention\u2010deficit\/hyperactivity disorder (\n ADHD<\/jats:styled-content>\n ) and their impact among adults with epilepsy from a large community\u2010based survey.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Adults who self\u2010reported epilepsy were sent a postal survey including the Adult\n ADHD<\/jats:styled-content>\n Self\u2010Report Scale version 6 (\n ASRS<\/jats:styled-content>\n \u20106), Physicians Health Questionnaire (\n PHQ<\/jats:styled-content>\n \u20109), Generalized Anxiety Disorder Assessment 7 (\n GAD<\/jats:styled-content>\n \u20107), and questions about seizure frequency and number of antiepileptic drugs (\n AED<\/jats:styled-content>\n s) during the preceding 3 months. Individuals with\n ASRS\u20106<\/jats:styled-content>\n scores >14 were classified as\n ASRS<\/jats:styled-content>\n +, and those with lower scores as\n ASRS<\/jats:styled-content>\n \u2212. Outcome measures included the Quality of Life in Epilepsy Inventory 10 (\n QOLIE<\/jats:styled-content>\n \u201010), Quality of Life and Enjoyment and Satisfaction Questionnaire (Q\u2010\n LES<\/jats:styled-content>\n \u2010Q), and the Sheehan Disability Scale (\n SDS<\/jats:styled-content>\n ). The relationship of\n ADHD<\/jats:styled-content>\n symptoms to quality of life outcomes was modeled hierarchically, with linear regression controlling for sociodemographic covariates, comorbid depression and anxiety, seizure frequency, and number of\n AED<\/jats:styled-content>\n s.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 1,361 of respondents with active epilepsy, 18.4% (n\u00a0=\u00a0251) were classified as\n ASRS<\/jats:styled-content>\n + and at risk for\n ADHD<\/jats:styled-content>\n . Compared to\n ASRS<\/jats:styled-content>\n \u2212 cases,\n ASRS<\/jats:styled-content>\n + individuals were more likely to have elevated depression and anxiety scores as well as greater seizure frequency and more AED use (p\u00a0<\u00a00.05 for all). Modeling results comparing\n ASRS<\/jats:styled-content>\n + and\n ASRS<\/jats:styled-content>\n \u2212 cases, controlling for all covariates, indicated\n that ASRS<\/jats:styled-content>\n + cases had lower quality of life (Beta [\u03b2]\u00a0=\u00a0\u22123.07, 95% confidence interval [CI] \u22124.19 to \u22121.96) and worse physical (\u03b2\u00a0=\u00a0\u22120.048 95%\n CI<\/jats:styled-content>\n \u22120.076 to \u22120.020) and social functioning (\u03b2\u00a0=\u00a0\u22120.058, 95%\n CI<\/jats:styled-content>\n \u22120.081 to \u22120.035) on the Q\u2010\n LES<\/jats:styled-content>\n \u2010Q, and increases in family (\u03b2\u00a0=\u00a01.57, 95%\n CI<\/jats:styled-content>\n 1.09\u20132.05), social (\u03b2\u00a0=\u00a01.68, 95%\n CI<\/jats:styled-content>\n 1.20\u20132.16), and work\u2010related disability (\u03b2\u20101.86, 95%\n CI<\/jats:styled-content>\n 1.27\u20132.46).\n <\/jats:p>\n <\/jats:sec>\n \n Significance<\/jats:title>\n \n ADHD<\/jats:styled-content>\n symptoms occur in nearly one of five adults with epilepsy, and are associated with increased psychosocial morbidity and lowered\n QOL<\/jats:styled-content>\n . Future studies should clarify the nature and causes of\n ADHD<\/jats:styled-content>\n symptoms in adults with epilepsy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/epi.12897","type":"journal-article","created":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T14:59:05Z","timestamp":1421333945000},"page":"218-224","source":"Crossref","is-referenced-by-count":47,"title":["Attention\u2010deficit\/hyperactivity disorder symptoms in adults with self\u2010reported epilepsy: Results from a national epidemiologic survey of epilepsy"],"prefix":"10.1111","volume":"56","author":[{"given":"Alan B.","family":"Ettinger","sequence":"first","affiliation":[{"name":"Neurological Surgery PC Lake Success New York U.S.A"},{"name":"Albert Einstein College of Medicine Bronx New York U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Ottman","sequence":"additional","affiliation":[{"name":"G.H. Sergievsky Center and Department of Neurology College of Physicians & Surgeons New York New York U.S.A"},{"name":"Department of Epidemiology Mailman School of Public Health Columbia University New York New York U.S.A"},{"name":"Division of Epidemiology New York State Psychiatric Institute New York New York U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Lipton","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine Bronx New York U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce A.","family":"Cramer","sequence":"additional","affiliation":[{"name":"Consultant Houston Texas U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina M.","family":"Fanning","sequence":"additional","affiliation":[{"name":"Vedanta Research Chapel Hill North Carolina U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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