{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:18:06Z","timestamp":1793215086344,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T00:00:00Z","timestamp":1424217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Seizures are common in patients with posterior reversible encephalopathy syndrome (<jats:styled-content style=\"fixed-case\">PRES<\/jats:styled-content>), which is reported in up to 70% of cases, and antiepileptic drugs (<jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s) are commonly prescribed. There is a paucity of data regarding the risk of subsequent seizures following resolution of <jats:styled-content style=\"fixed-case\">PRES<\/jats:styled-content>, and therefore the optimal duration of treatment with <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s is currently unknown. The objective of this study was to identify the frequency of recurrent seizures and epilepsy following recovery from <jats:styled-content style=\"fixed-case\">PRES<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective review of consecutive adults diagnosed with <jats:styled-content style=\"fixed-case\">PRES<\/jats:styled-content> between 2000 and 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred twenty\u2010seven patients, median age 53\u00a0years (interquartile range [<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>] 37\u201364), were included in the analysis. The most common causes of <jats:styled-content style=\"fixed-case\">PRES<\/jats:styled-content> were hypertension (72%) and immunosuppression (20%). Renal failure was present in 47%. Eighty\u2010four patients (66%) had seizures at presentation (39 focal, 45 generalized), and 13 (15%) of them presented with status epilepticus. Median duration of follow\u2010up was 3.2\u00a0years (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 4\u00a0months to 6.9\u00a0years). Patients with seizures were treated with <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s for a median of 3\u00a0months (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 2\u20137). Fifteen patients (12%) had provoked seizures during the follow\u2010up period; in eight (53%) patients seizures were caused by recurrent <jats:styled-content style=\"fixed-case\">PRES<\/jats:styled-content>. Only three patients had subsequent unprovoked seizures, one of whom was considered to have developed epilepsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>We conclude that unprovoked seizures and epilepsy are uncommon in patients who have recovered from <jats:styled-content style=\"fixed-case\">PRES<\/jats:styled-content>. Discontinuation of <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s following resolution of <jats:styled-content style=\"fixed-case\">PRES<\/jats:styled-content> should be considered, provided there is adequate control of risk factors, and absence of factors that could substantially lower the seizure threshold.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.12933","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T07:44:59Z","timestamp":1424245499000},"page":"564-568","source":"Crossref","is-referenced-by-count":74,"title":["Long\u2010term risk of seizures and epilepsy in patients with posterior reversible encephalopathy syndrome"],"prefix":"10.1111","volume":"56","author":[{"given":"Sudhir","family":"Datar","sequence":"first","affiliation":[{"name":"Department of Neurology Division of Critical Care Neurology Wake Forest Baptist Health Winston Salem North Carolina U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Neurology Division of Critical Care Neurology Mayo Clinic Rochester Minnesota U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro A.","family":"Rabinstein","sequence":"additional","affiliation":[{"name":"Department of Neurology Division of Critical Care Neurology Mayo Clinic Rochester Minnesota U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E.","family":"Fugate","sequence":"additional","affiliation":[{"name":"Department of Neurology Division of Critical Care Neurology Mayo Clinic Rochester Minnesota U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Hocker","sequence":"additional","affiliation":[{"name":"Department of Neurology Division of Critical Care Neurology Mayo Clinic Rochester Minnesota U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602223340803"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2009.0590"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.119"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2007.46"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2011.03.011"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0549"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520340032007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6362-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000269780.45472.16"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-008-1059-2"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.29.11.1480"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000078031.32904.0D"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2010.01.014"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2010.10.005"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100007332"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-200203000-00009"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.12933","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.12933","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T19:12:03Z","timestamp":1696360323000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.12933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,18]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/epi.12933"],"URL":"https:\/\/doi.org\/10.1111\/epi.12933","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,18]]}}}