{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:17:34Z","timestamp":1788671854100,"version":"build-2803163510"},"reference-count":8,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T00:00:00Z","timestamp":1429488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National Institutes of Health\/National Institute of Neurological Disorders and Stroke (NIH\/NINDS)"},{"name":"Barron Associates"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2015,6]]},"abstract":"Summary<\/jats:title>Objective<\/jats:title>Electrocorticographic (EC<\/jats:styled-content>oG) recordings from patients with medically intractable partial\u2010onset seizures treated with a responsive neurostimulator system (the RNS<\/jats:styled-content> System) that detects and stores physician\u2010specified EC<\/jats:styled-content>oG events provide a new data resource. Interpretation of these recordings has not yet been validated. The purpose was to evaluate the interrater interpretation of chronic ambulatory EC<\/jats:styled-content>oG recordings obtained by the RNS<\/jats:styled-content> System.<\/jats:p><\/jats:sec>Methods<\/jats:title>Five pairs of five experts independently classified 7,221 EC<\/jats:styled-content>oG recordings obtained from 128 patients with medically intractable partial seizures who participated in a randomized controlled trial of the safety and efficacy of the RNS<\/jats:styled-content> System. EC<\/jats:styled-content>oG detections\u2014\u201clong episodes\u201d or \u201csaturations\u201d\u2014were classified as \u201cseizures\u201d or \u201cnot seizures\u201d based on a reference definition. Interrater agreement rates and kappa score reliabilities were calculated between rater pairs from the EC<\/jats:styled-content>oG sample as a whole and within individual patients who had more than the median number of individual EC<\/jats:styled-content>oG recordings.<\/jats:p><\/jats:sec>Results<\/jats:title>The overall interrater agreement was 79%, with a reliability \u03ba\u00a0=\u00a00.57 (moderate agreement). Agreement between pairs of reviewers ranged from 0.69 to 0.85. Agreement rates were 94% or better for 50% of patients. Only 25% of patients had EC<\/jats:styled-content>oG recordings agreement rates worse than 75%. EC<\/jats:styled-content>oGs with mixed interpretations (one reviewer \u201cseizure\u201d\/the other\u2014\u201cnot seizure\u201d) consisted of periods of low amplitude activity that evolved in amplitude or periodic discharges near 2\u00a0Hz.<\/jats:p><\/jats:sec>Significance<\/jats:title>Although reliability as a whole was moderate, for the majority of patients, detections yielded highly reliably interpreted events of either electrographic seizures or nonictal epileptiform activity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.12998","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T09:43:36Z","timestamp":1429523016000},"page":"968-971","source":"Crossref","is-referenced-by-count":29,"title":["Interrater reliability in interpretation of electrocorticographic seizure detections of the responsive neurostimulator"],"prefix":"10.1111","volume":"56","author":[{"given":"Mark","family":"Quigg","sequence":"first","affiliation":[{"name":"Department of Neurology University of Virginia Charlottesville Virginia U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Sun","sequence":"additional","affiliation":[{"name":"NeuroPace Inc Mountain View California U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan B.","family":"Fountain","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Virginia Charlottesville Virginia U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara C.","family":"Jobst","sequence":"additional","affiliation":[{"name":"Department of Neurology Dartmouth University Lebanon New Hampshire U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria S. S.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Neurology Oregon Health and Science University Portland Oregon U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Mirro","sequence":"additional","affiliation":[{"name":"NeuroPace Inc Mountain View California U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Neurology Oregon Health and Science University Portland Oregon U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Spencer","sequence":"additional","affiliation":[{"name":"Department of Neurology Oregon Health and Science University Portland Oregon U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-195407000-00024"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2002.11102.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182302056"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12534"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000308938.84918.3f"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0031619"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12270"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.6238"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.12998","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.12998","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.12998","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/epi.12998","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.12998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T10:58:05Z","timestamp":1696330685000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.12998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,20]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/epi.12998"],"URL":"https:\/\/doi.org\/10.1111\/epi.12998","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,20]]}}}