{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T13:37:32Z","timestamp":1783777052263,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T00:00:00Z","timestamp":1433376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dutch Epilepsy Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe treatment and outcome of epilepsy in children with tuberous sclerosis complex (<jats:styled-content style=\"fixed-case\">TSC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010one children with <jats:styled-content style=\"fixed-case\">TSC<\/jats:styled-content> and epilepsy treated at the <jats:styled-content style=\"fixed-case\">ENCORE TSC<\/jats:styled-content> Expertise Center between 1988 and 2014 were included. Patient characteristics and duration and effectiveness of antiepileptic treatments were extracted from our clinical database. Correlations were made between recurrence of seizures after response to treatment, and several patient characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age at time of inclusion was 9.4\u00a0years (range 0.9\u201318.0). Seizure history showed that 55 children (77%) of 71 became seizure\u2010free for longer than 1\u00a0month, and 21 (30%) of 71 for longer than 24\u00a0months. Remission of seizures was associated with higher <jats:styled-content style=\"fixed-case\">IQ<\/jats:styled-content>, and a trend was observed between seizure remission and age at onset of seizures. A total of 19 antiepileptic drugs (<jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s) were used. Valproic acid, vigabatrin, levetiracetam, and carbamazepine were used most frequently. Nonpharmacologic therapies (ketogenic diet, epilepsy surgery, and vagus nerve stimulation) were used 13 times. Epilepsy surgery was most effective, with four of five children becoming seizure\u2010free. <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s prescribed as first and second treatment were most effective. Valproic acid was prescribed most frequently as first and second treatment, followed by vigabatrin. Thirty\u2010one children had infantile spasms, preceded by focal seizures in 18 children (58%). Vigabatrin was used by 29 children (94%), and was first treatment in 15 (48%). Vigabatrin was more effective than other <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s when prescribed as first treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>We showed that, although 77% of children with epilepsy due to <jats:styled-content style=\"fixed-case\">TSC<\/jats:styled-content> reached seizure remission, usually after their first or second <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>, this was sustained for at least 24\u00a0months in only 38%. Almost half of those with 24 months of remission later had relapse of seizures. Our results support vigabatrin as first choice drug, and show the need for better treatment options for these children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.13050","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T15:32:08Z","timestamp":1433431928000},"page":"1239-1245","source":"Crossref","is-referenced-by-count":98,"title":["Epilepsy in children with tuberous sclerosis complex: Chance of remission and response to antiepileptic drugs"],"prefix":"10.1111","volume":"56","author":[{"given":"Iris E.","family":"Overwater","sequence":"first","affiliation":[{"name":"Department of Neurology Erasmus MC\u2010Sophia Children's Hospital Rotterdam The Netherlands"},{"name":"ENCORE TSC Expertise Center Erasmus MC\u2010Sophia Children's Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Bindels\u2010de Heus","sequence":"additional","affiliation":[{"name":"ENCORE TSC Expertise Center Erasmus MC\u2010Sophia Children's Hospital Rotterdam The Netherlands"},{"name":"Department of Pediatrics Erasmus MC\u2010Sophia Children's Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 B.","family":"Rietman","sequence":"additional","affiliation":[{"name":"Department of Neurology Erasmus MC\u2010Sophia Children's Hospital Rotterdam The Netherlands"},{"name":"ENCORE TSC Expertise Center Erasmus MC\u2010Sophia Children's Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leontine W.","family":"ten Hoopen","sequence":"additional","affiliation":[{"name":"ENCORE TSC Expertise Center Erasmus MC\u2010Sophia Children's Hospital Rotterdam The Netherlands"},{"name":"Department of Child and Adolescent Psychiatry\/Psychology Erasmus MC\u2010Sophia Children's Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Vergouwe","sequence":"additional","affiliation":[{"name":"Department of Public Health Erasmus MC Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henriette A.","family":"Moll","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Erasmus MC\u2010Sophia Children's Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Claire Y.","family":"de Wit","sequence":"additional","affiliation":[{"name":"Department of Neurology Erasmus MC\u2010Sophia Children's Hospital Rotterdam The Netherlands"},{"name":"ENCORE TSC Expertise Center Erasmus MC\u2010Sophia Children's Hospital Rotterdam The 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