{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:28:39Z","timestamp":1785536919609,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T00:00:00Z","timestamp":1438905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001837","name":"Eesti Teadusfondi","doi-asserted-by":"publisher","award":["9309"],"award-info":[{"award-number":["9309"]}],"id":[{"id":"10.13039\/501100001837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Valproate (<jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content>) treatment has been reported to be associated with weight gain and metabolic changes, such as hyperinsulinemia. The question of whether hyperinsulinemia and other metabolic changes are consequences of increased weight, or are instead direct results of <jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content> treatment, remains a matter of debate. The aim of the current study was to explore the influence of <jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content> treatment on glucose and insulin levels during the oral glucose tolerance test (<jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content>) directly following the first intravenous (<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>) administration. Sixteen patients (18\u201346\u00a0years old) with newly diagnosed epilepsy underwent an <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content> with 75\u00a0g glucose prior to the start of <jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content> treatment, as well as directly following the first <jats:styled-content style=\"fixed-case\">IV VPA<\/jats:styled-content> administration. We observed that plasma glucose levels during the 120\u00a0min of <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content> session following infusion of <jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content> were significantly lower than those measured during <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content> without <jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content> treatment (mean \u00b1 standard deviation [SD] 4.28\u00a0\u00b1\u00a00.94\u00a0mmol\/l vs. 4.75\u00a0\u00b1\u00a01.09\u00a0mmol\/l respectively, p\u00a0=\u00a00.038). However, blood concentrations of insulin and C\u2010peptide did not differ significantly between the two measurements. This is the first study to show a potential acute glucose\u2010lowering effect of <jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content> during <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content> in patients with newly diagnosed epilepsy.<\/jats:p>","DOI":"10.1111\/epi.13114","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T06:44:27Z","timestamp":1438929867000},"source":"Crossref","is-referenced-by-count":29,"title":["Valproate modulates glucose metabolism in patients with epilepsy after first exposure"],"prefix":"10.1111","volume":"56","author":[{"given":"Aleksei","family":"Rakitin","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery University of Tartu Tartu Estonia"},{"name":"Neurology Clinic Tartu University Hospital Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulev","family":"K\u00f5ks","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology University of Tartu Tartu Estonia"},{"name":"Center of Translational Medicine University of Tartu Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulev","family":"Haldre","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery University of Tartu Tartu Estonia"},{"name":"Neurology Clinic Tartu University Hospital Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2010.00800.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2013.08.016"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00546.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(03)00091-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02522.x"},{"key":"e_1_2_7_7_1","first-page":"45","article-title":"The effect of valproate on blood metabolite concentrations in spontaneously diabetic, ketoacidotic, BB\/E Wistar rats","volume":"2","author":"Turnbull DM","year":"1985","journal-title":"Diabetes Res"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-011-0088-0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03439"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-013-0294-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2002.34708"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/35007534"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.2.271"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2006.12.009"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2011.00021"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2011.03.008"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.13114","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.13114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T17:42:20Z","timestamp":1694972540000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.13114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,7]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/epi.13114"],"URL":"https:\/\/doi.org\/10.1111\/epi.13114","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,7]]}}}