{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T22:23:16Z","timestamp":1786659796940,"version":"build-2736575974"},"reference-count":58,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T00:00:00Z","timestamp":1446595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institute of Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CEPID-FAPESP: \u201cThe Brazilian Institute of Neuroscience and Neurotechnology (BRAINN)\u201d","award":["2013\/07559-3"],"award-info":[{"award-number":["2013\/07559-3"]}]},{"name":"Brazilian National Council for Scientific and Technological Development (CNPq)-(GCB)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Although altered large\u2010scale brain network organization in patients with temporal lobe epilepsy (<jats:styled-content style=\"fixed-case\">TLE<\/jats:styled-content>) has been shown using morphologic measurements such as cortical thickness, these studies, have not included critical subcortical structures (such as hippocampus and amygdala) and have had relatively small sample sizes. Here, we investigated differences in topological organization of the brain volumetric networks between patients with right TLE (<jats:styled-content style=\"fixed-case\">RTLE<\/jats:styled-content>) and left TLE (<jats:styled-content style=\"fixed-case\">LTLE<\/jats:styled-content>) with unilateral hippocampal atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a cross\u2010sectional analysis of 86 <jats:styled-content style=\"fixed-case\">LTLE<\/jats:styled-content> patients, 70 <jats:styled-content style=\"fixed-case\">RTLE<\/jats:styled-content> patients, and 116 controls. <jats:styled-content style=\"fixed-case\">RTLE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LTLE<\/jats:styled-content> groups were balanced for gender (p = 0.64), seizure frequency (Mann\u2010Whitney <jats:italic>U<\/jats:italic> test, p = 0.94), age (p = 0.39), age of seizure onset (p = 0.21), and duration of disease (p = 0.69). Brain networks were constructed by thresholding correlation matrices of volumes from 80 cortical\/subcortical regions (parcellated with Freesurfer v5.3 <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/surfer.nmr.mgh.harvard.edu\/\">https:\/\/surfer.nmr.mgh.harvard.edu\/<\/jats:ext-link>) that were then analyzed using graph theoretical approaches.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified reduced cortical\/subcortical connectivity including bilateral hippocampus in both <jats:styled-content style=\"fixed-case\">TLE<\/jats:styled-content> groups, with the most significant interregional correlation increases occurring within the limbic system in <jats:styled-content style=\"fixed-case\">LTLE<\/jats:styled-content> and contralateral hemisphere in <jats:styled-content style=\"fixed-case\">RTLE<\/jats:styled-content>. Both <jats:styled-content style=\"fixed-case\">TLE<\/jats:styled-content> groups demonstrated less optimal topological organization, with decreased global efficiency and increased local efficiency and clustering coefficient. <jats:styled-content style=\"fixed-case\">LTLE<\/jats:styled-content> also displayed a more pronounced network disruption. Contrary to controls, hub nodes in both <jats:styled-content style=\"fixed-case\">TLE<\/jats:styled-content> groups were not distributed across whole brain, but rather found primarily in the paralimbic\/limbic and temporal association cortices. Regions with increased centrality were concentrated in occipital lobes for <jats:styled-content style=\"fixed-case\">LTLE<\/jats:styled-content> and contralateral limbic\/temporal areas for <jats:styled-content style=\"fixed-case\">RTLE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>These findings provide first evidence of altered topological organization of the whole brain volumetric network in <jats:styled-content style=\"fixed-case\">TLE<\/jats:styled-content>, with disruption of the coordinated patterns of cortical\/subcortical morphology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.13225","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T06:02:46Z","timestamp":1446616966000},"page":"1992-2002","source":"Crossref","is-referenced-by-count":71,"title":["Aberrant topological patterns of brain structural network in temporal lobe epilepsy"],"prefix":"10.1111","volume":"56","author":[{"given":"Clarissa Lin","family":"Yasuda","sequence":"first","affiliation":[{"name":"Division of Neurology Department of Medicine University of Alberta Edmonton Alberta Canada"},{"name":"Laboratory of Neuroimaging Department of Neurology University of Campinas Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Coco","family":"Beltramini","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroimaging Department of Neurology University of Campinas Campinas Brazil"},{"name":"Institute of Physics \u201cGleb Wataghin\u201d University of Campinas Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina","family":"Coan","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroimaging Department of Neurology University of Campinas Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia Elisabete","family":"Morita","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroimaging Department of Neurology University of Campinas Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Kubota","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroimaging Department of Neurology University of Campinas Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Bergo","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroimaging Department of Neurology University of Campinas Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Beaulieu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Cendes","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroimaging Department of Neurology University of Campinas Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald William","family":"Gross","sequence":"additional","affiliation":[{"name":"Division of Neurology Department of Medicine University of Alberta Edmonton Alberta 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