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To date, only aggressive medical and surgical efforts to control seizures have been demonstrated to be of benefit. Incomplete understanding of <jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content> mechanisms limits the development of more specific interventions. Periictal cardiorespiratory dysfunction is implicated in <jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content>; postictal electroencephalography (<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>) suppression, coma, and immobility may also play a role. Nocturnal supervision is protective against <jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content>, presumably by permitting intervention in the case of a life\u2010threatening event. Resuscitative efforts were implemented promptly in near\u2010<jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content> cases but delayed in <jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content> deaths in the Mortality in Epilepsy Monitoring Unit Study (MORTEMUS) study. Nursing interventions\u2014including repositioning, oral suctioning, and oxygen administration\u2014reduce seizure duration, respiratory dysfunction, and <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content> suppression in the epilepsy monitoring unit (<jats:styled-content style=\"fixed-case\">EMU<\/jats:styled-content>), but have not been studied in outpatients. Cardiac pacemakers or cardioverter\u2010defibrillator devices may be of benefit in a few select individuals. A role for implantable neurostimulators has not yet been established. Seizure detection devices, including those that monitor generalized tonic\u2013clonic seizure\u2010associated movements or cardiorespiratory parameters, may provide a means to permit timely periictal intervention. However, these and other devices, such as antisuffocation pillows, have not been adequately investigated with respect to <jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content> prevention.<\/jats:p>","DOI":"10.1111\/epi.13231","type":"journal-article","created":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T03:13:40Z","timestamp":1452654820000},"page":"26-34","source":"Crossref","is-referenced-by-count":32,"title":["From unwitnessed fatality to witnessed rescue: Nonpharmacologic interventions in sudden unexpected death in epilepsy"],"prefix":"10.1111","volume":"57","author":[{"given":"Fergus","family":"Rugg\u2010Gunn","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy UCL Institute of Neurology NIHR University College London Hospitals Biomedical Research Centre London United Kingdom"},{"name":"Chalfont Centre for Epilepsy Chalfont St. Peter United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Duncan","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy UCL Institute of Neurology NIHR University College London Hospitals Biomedical Research Centre London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle","family":"Hjalgrim","sequence":"additional","affiliation":[{"name":"Danish Epilepsy Center Filadelfia Dianalund Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masud","family":"Seyal","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California Davis Sacramento California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Bateman","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University New York New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60176-1"},{"issue":"2","key":"e_1_2_10_3_1","first-page":"35","article-title":"From unwitnessed fatality to witnessed rescue: Pharmacological intervention in sudden unexpected death in epilepsy","volume":"56","author":"Richerson GB","year":"2015","journal-title":"Epilepsia"},{"issue":"2","key":"e_1_2_10_4_1","first-page":"4","article-title":"Who to target in sudden unexpected death in epilepsy prevention and how? 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