{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:14:48Z","timestamp":1783649688233,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T00:00:00Z","timestamp":1447977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Summary<\/jats:title>This study aimed to evaluate the prevalence and the relationship of sleep breathing disorders (SBD<\/jats:styled-content>s) and laryngeal motility alterations in patients with drug\u2010resistant epilepsy after vagus nerve stimulator (VNS<\/jats:styled-content>) implantation. Twenty\u2010three consecutive patients with medically refractory epilepsy underwent out\u2010of\u2010center sleep testing before and after VNS<\/jats:styled-content> implantation. Eighteen eligible subjects underwent endoscopic laryngeal examination post\u2010VNS<\/jats:styled-content> implantation. Statistical analysis was carried out to assess an association between laryngeal motility alterations and the onset\/worsening of SBD<\/jats:styled-content>s. After VNS<\/jats:styled-content> implantation, 11 patients showed a new\u2010onset mild\/moderate SBD<\/jats:styled-content>. Half of the patients already affected by obstructive sleep apnea (OSA) showed worsening of SBD<\/jats:styled-content>. All of the patients with a new\u2010onset OSA<\/jats:styled-content> had a laryngeal pattern with left vocal cord adduction (LVCA<\/jats:styled-content>) during VNS<\/jats:styled-content> stimulation. The association between VNS<\/jats:styled-content>\u2010induced LVCA<\/jats:styled-content> and SBD<\/jats:styled-content> was statistically significant. This study suggests an association between VNS<\/jats:styled-content> and SBD<\/jats:styled-content>, hinting to a pivotal role of laryngeal motility alterations. The relationship between SBD<\/jats:styled-content> and VNS<\/jats:styled-content>\u2010induced LVCA<\/jats:styled-content> supports the need to routinely investigate sleep respiratory and laryngeal motility patterns before and after VNS<\/jats:styled-content> implantation.<\/jats:p>","DOI":"10.1111\/epi.13252","type":"journal-article","created":{"date-parts":[[2015,11,21]],"date-time":"2015-11-21T04:51:01Z","timestamp":1448081461000},"source":"Crossref","is-referenced-by-count":60,"title":["Laryngeal motility alteration: A missing link between sleep apnea and vagus nerve stimulation for epilepsy"],"prefix":"10.1111","volume":"57","author":[{"given":"Elena","family":"Zambrelli","sequence":"first","affiliation":[{"name":"Epilepsy Center \u2013 Sleep Medicine Center San Paolo Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto M.","family":"Saibene","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology San Paolo Hospital Milan Italy"},{"name":"Department of Health Sciences University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Furia","sequence":"additional","affiliation":[{"name":"Epilepsy Center \u2013 Sleep Medicine Center San Paolo Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Chiesa","sequence":"additional","affiliation":[{"name":"Epilepsy Center \u2013 Sleep Medicine Center San Paolo Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aglaia","family":"Vignoli","sequence":"additional","affiliation":[{"name":"Epilepsy Center \u2013 Sleep Medicine Center San Paolo Hospital Milan Italy"},{"name":"Department of Health Sciences University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Pipolo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology San Paolo Hospital Milan Italy"},{"name":"Department of Health Sciences University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Felisati","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology San Paolo Hospital Milan Italy"},{"name":"Department of Health Sciences University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paola","family":"Canevini","sequence":"additional","affiliation":[{"name":"Epilepsy Center \u2013 Sleep Medicine Center San Paolo Hospital Milan Italy"},{"name":"Department of Health Sciences University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.10.1450"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000086812.62554.06"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2003.56202.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.8.1523"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2007.09.014"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-007-0404-8"},{"key":"e_1_2_8_8_1","unstructured":"Cyberonics Inc.VNS therapy products manuals and safety alerts: Part I \u2013 Introduction \u2013 Intended use \u2010 Indications Warnings p. 3\u201018. 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